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Gene Review

P2RY6  -  pyrimidinergic receptor P2Y, G-protein...

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Synonyms: P2RY3, P2Y3
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High impact information on P2RY6

  • Expression of P2Y3 in cRNA-injected Xenopus oocytes confirmed that this cDNA encodes a member of the metabotropic purinoceptor family, with a novel order for the relative activities of nucleotides [1].
  • When expressed in the human T cell line Jurkat, P2Y3 mediated transient increases in intracellular Ca2+ in response to various nucleotides [1].
  • After extension to full length, it revealed an open reading frame that encoded a protein, P2Y3, of 328 amino acids that is nearest in sequence identity to the G protein-coupled P2 purinoceptors obtained by DNA cloning [1].


  1. A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates. Webb, T.E., Henderson, D., King, B.F., Wang, S., Simon, J., Bateson, A.N., Burnstock, G., Barnard, E.A. Mol. Pharmacol. (1996) [Pubmed]
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