Gene Review:
P2RY6 - pyrimidinergic receptor P2Y, G-protein...
Homo sapiens
Synonyms:
P2Y purinoceptor 6, P2Y6, PP2891
Communi,
Paindavoine,
Place,
Parmentier,
Boeynaems,
von Kügelgen,
Wihlborg,
Balogh,
Wang,
Borna,
Dou,
Joshi,
Lazarowski,
Jacobson,
Arner,
Erlinge,
Malmsjö,
Hou,
Pendergast,
Erlinge,
Edvinsson,
Somers,
Hammet,
Woollatt,
Richards,
Southey,
Venter,
von Kügelgen,
Wetter,
Nicholas,
Watt,
Lazarowski,
Li,
Harden,
- Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. Lee, H., Choi, B.H., Suh, B.C., Lee, S.K., Kim, K.T. J. Neurochem. (2003)
- The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP. Cox, M.A., Gomes, B., Palmer, K., Du, K., Wiekowski, M., Wilburn, B., Petro, M., Chou, C.C., Desquitado, C., Schwarz, M., Lunn, C., Lundell, D., Narula, S.K., Zavodny, P.J., Jenh, C.H. Biochem. Biophys. Res. Commun. (2005)
- Expression of the P2Y6 purinergic receptor in human T cells infiltrating inflammatory bowel disease. Somers, G.R., Hammet, F.M., Trute, L., Southey, M.C., Venter, D.J. Lab. Invest. (1998)
- Potent P2Y6 receptor mediated contractions in human cerebral arteries. Malmsjö, M., Hou, M., Pendergast, W., Erlinge, D., Edvinsson, L. BMC Pharmacol. (2003)
- Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. Nicholas, R.A., Lazarowski, E.R., Watt, W.C., Li, Q., Boyer, J., Harden, T.K. Journal of autonomic pharmacology. (1996)
- Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. Khine, A.A., Del Sorbo, L., Vaschetto, R., Voglis, S., Tullis, E., Slutsky, A.S., Downey, G.P., Zhang, H. Blood (2006)
- Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. Ahmad, S., Ahmad, A., Ghosh, M., Leslie, C.C., White, C.W. J. Biol. Chem. (2004)
- Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. Brinson, A.E., Harden, T.K. J. Biol. Chem. (2001)
- Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. Akbar, G.K., Dasari, V.R., Webb, T.E., Ayyanathan, K., Pillarisetti, K., Sandhu, A.K., Athwal, R.S., Daniel, J.L., Ashby, B., Barnard, E.A., Kunapuli, S.P. J. Biol. Chem. (1996)
- Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. von Kügelgen, I. Pharmacol. Ther. (2006)
- P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis. Kim, S.G., Gao, Z.G., Soltysiak, K.A., Chang, T.S., Brodie, C., Jacobson, K.A. Cell. Mol. Neurobiol. (2003)
- Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. Somers, G.R., Hammet, F., Woollatt, E., Richards, R.I., Southey, M.C., Venter, D.J. Genomics (1997)
- Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. Maier, R., Glatz, A., Mosbacher, J., Bilbe, G. Biochem. Biophys. Res. Commun. (1997)
- Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1. Pidlaoan, L.V., Jin, J., Sandhu, A.K., Athwal, R.S., Kunapuli, S.P. Somat. Cell Mol. Genet. (1997)
- CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Mamedova, L., Capra, V., Accomazzo, M.R., Gao, Z.G., Ferrario, S., Fumagalli, M., Abbracchio, M.P., Rovati, G.E., Jacobson, K.A. Biochem. Pharmacol. (2005)
- Membrane-specific expression of functional purinergic receptors in normal human nasal epithelial cells. Kim, C.H., Kim, S.S., Choi, J.Y., Shin, J.H., Kim, J.Y., Namkung, W., Lee, J.G., Lee, M.G., Yoon, J.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- Molecular pharmacology of P2Y-receptors. von Kügelgen, I., Wetter, A. Naunyn Schmiedebergs Arch. Pharmacol. (2000)
- Characterization of the biological activities of uridine diphosphate in human dendritic cells: Influence on chemotaxis and CXCL8 release. Idzko, M., Panther, E., Sorichter, S., Herouy, Y., Berod, L., Geissler, M., Mockenhaupt, M., Elsner, P., Girolomoni, G., Norgauer, J. J. Cell. Physiol. (2004)
- ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. Schafer, R., Sedehizade, F., Welte, T., Reiser, G. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Expression of P2Y receptors in cell lines derived from the human lung. Communi, D., Paindavoine, P., Place, G.A., Parmentier, M., Boeynaems, J.M. Br. J. Pharmacol. (1999)
- Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Nicholas, R.A., Watt, W.C., Lazarowski, E.R., Li, Q., Harden, K. Mol. Pharmacol. (1996)
- Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors. Kim, S.G., Soltysiak, K.A., Gao, Z.G., Chang, T.S., Chung, E., Jacobson, K.A. Biochem. Pharmacol. (2003)
- Differential signalling of purinoceptors in HeLa cells through the extracellular signal-regulated kinase and protein kinase C pathways. Muscella, A., Greco, S., Elia, M.G., Storelli, C., Marsigliante, S. J. Cell. Physiol. (2004)
- Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with intact endothelium. Wang, L., Andersson, M., Karlsson, L., Watson, M.A., Cousens, D.J., Jern, S., Erlinge, D. Arterioscler. Thromb. Vasc. Biol. (2003)
- Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. Maier, R., Glatz, A., Mosbacher, J., Bilbe, G. Biochem. Biophys. Res. Commun. (1997)
- Activation of P2Y2 purinoceptor inhibits the activity of the Na+/K+-ATPase in HeLa cells. Muscella, A., Elia, M.G., Greco, S., Storelli, C., Marsigliante, S. Cell. Signal. (2003)
- Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Wihlborg, A.K., Balogh, J., Wang, L., Borna, C., Dou, Y., Joshi, B.V., Lazarowski, E., Jacobson, K.A., Arner, A., Erlinge, D. Circ. Res. (2006)