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Gene Review:

P2ry6 - pyrimidinergic receptor P2Y, G-protein...

Mus musculus

Synonyms: 2010204J23Rik, P2Y purinoceptor 6, P2Y6

Schreiber, R. et al., Vonend, O. et al., Chen, B.C. et al., Matos, J.E. et al., Guns, P.J. et al.

Schreiber, Kunzelmann, Guns, Van Assche, Fransen, Robaye, Boeynaems, Bult,

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High impact information on P2ry6

RT-PCR analysis of isolated colonic crypts revealed P2Y2, P2Y4 and P2Y6 specific transcripts [1].
UTP, via acting on P2Y6 receptors, can stimulate phosphoinositide (PI) turnover and transient [Ca2+]i increase, however, it did not possess the NO priming effect [2].
For UTP, it was unclear whether P2Y2, P2Y6 or yet another subtype was involved [3].
Pretreatment with the P2X(1,3)-receptor agonist alpha,beta-meATP potentiated P2Y6-like receptor-mediated vasoconstrictions [4].
Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney [4].

Anatomical context of P2ry6

Here we show that these metabolites change electrolyte transport by stimulation of P2Y6 receptors in mouse trachea [5].

Associations of P2ry6 with chemical compounds

In Ussing chamber experiments luminal ADP, UDP or the P2Y6 receptor agonist INS48823 induced both transient and persistent increase in short circuit currents (ISC) [5].

Analytical, diagnostic and therapeutic context of P2ry6

Immunohistochemistry confirmed luminal and basolateral expression of P2Y6 receptors [5].

References

K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon. Matos, J.E., Robaye, B., Boeynaems, J.M., Beauwens, R., Leipziger, J. J. Physiol. (Lond.) (2005) [Pubmed]
Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages. Chen, B.C., Hsieh, S.L., Lin, W.W. J. Leukoc. Biol. (2001) [Pubmed]
Endothelium-dependent relaxation evoked by ATP and UTP in the aorta of P2Y2-deficient mice. Guns, P.J., Van Assche, T., Fransen, P., Robaye, B., Boeynaems, J.M., Bult, H. Br. J. Pharmacol. (2006) [Pubmed]
Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney. Vonend, O., Stegbauer, J., Sojka, J., Habbel, S., Quack, I., Robaye, B., Boeynaems, J.M., Rump, L.C. Br. J. Pharmacol. (2005) [Pubmed]
Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea. Schreiber, R., Kunzelmann, K. Cell. Physiol. Biochem. (2005) [Pubmed]

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