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P2ry6  -  pyrimidinergic receptor P2Y, G-protein...

Mus musculus

Synonyms: 2010204J23Rik, P2Y purinoceptor 6, P2Y6
 
 
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High impact information on P2ry6

  • RT-PCR analysis of isolated colonic crypts revealed P2Y2, P2Y4 and P2Y6 specific transcripts [1].
  • UTP, via acting on P2Y6 receptors, can stimulate phosphoinositide (PI) turnover and transient [Ca2+]i increase, however, it did not possess the NO priming effect [2].
  • For UTP, it was unclear whether P2Y2, P2Y6 or yet another subtype was involved [3].
  • Pretreatment with the P2X(1,3)-receptor agonist alpha,beta-meATP potentiated P2Y6-like receptor-mediated vasoconstrictions [4].
  • Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney [4].
 

Anatomical context of P2ry6

  • Here we show that these metabolites change electrolyte transport by stimulation of P2Y6 receptors in mouse trachea [5].
 

Associations of P2ry6 with chemical compounds

  • In Ussing chamber experiments luminal ADP, UDP or the P2Y6 receptor agonist INS48823 induced both transient and persistent increase in short circuit currents (ISC) [5].
 

Analytical, diagnostic and therapeutic context of P2ry6

References

  1. K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon. Matos, J.E., Robaye, B., Boeynaems, J.M., Beauwens, R., Leipziger, J. J. Physiol. (Lond.) (2005) [Pubmed]
  2. Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages. Chen, B.C., Hsieh, S.L., Lin, W.W. J. Leukoc. Biol. (2001) [Pubmed]
  3. Endothelium-dependent relaxation evoked by ATP and UTP in the aorta of P2Y2-deficient mice. Guns, P.J., Van Assche, T., Fransen, P., Robaye, B., Boeynaems, J.M., Bult, H. Br. J. Pharmacol. (2006) [Pubmed]
  4. Noradrenaline and extracellular nucleotide cotransmission involves activation of vasoconstrictive P2X(1,3)- and P2Y6-like receptors in mouse perfused kidney. Vonend, O., Stegbauer, J., Sojka, J., Habbel, S., Quack, I., Robaye, B., Boeynaems, J.M., Rump, L.C. Br. J. Pharmacol. (2005) [Pubmed]
  5. Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea. Schreiber, R., Kunzelmann, K. Cell. Physiol. Biochem. (2005) [Pubmed]
 
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