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Gene Review

LPAR6  -  lysophosphatidic acid receptor 6

Gallus gallus

Synonyms: P2RY5, P2Y5
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High impact information on P2RY5

  • Transcription of 6H1 is induced by a number of T cell stimuli and is inhibited by cyclosporin A, but not by cycloheximide [1].
  • The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses [2].
  • The 6H1 receptor cloned from activated chicken T cells was initially considered an orphan G-coupled receptor, but was later included in the P2Y family of receptors for purine and pyrimidine nucleotides on the basis of a significant amino acid identity and was renamed P2Y5 [3].
  • We have determined the identity of the orphan G-protein coupled receptor cDNA, 6H1, present in activated chicken T cells, as a subtype of P2Y purinoceptor [4].
  • Upon transient expression in COS-7 cells the 6H1 receptor bound the radiolabel [35S]dATP alpha S specifically and with high affinity (Kd, 10 nM) [4].


  1. Identification of a G protein coupled receptor induced in activated T cells. Kaplan, M.H., Smith, D.I., Sundick, R.S. J. Immunol. (1993) [Pubmed]
  2. The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Li, Q., Schachter, J.B., Harden, T.K., Nicholas, R.A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  3. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. Janssens, R., Boeynaems, J.M., Godart, M., Communi, D. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Identification of 6H1 as a P2Y purinoceptor: P2Y5. Webb, T.E., Kaplan, M.G., Barnard, E.A. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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