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Gene Review:

P2RY1 - purinergic receptor P2Y, G-protein coupled, 1

Gallus gallus

Webb, T.E. et al., Nakamura, F. et al., King, B.F. et al., Filtz, T.M. et al., Draid, M. et al., et al.

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Disease relevance of P2RY1

P2Y1 mRNA is concentrated in large-fiber dorsal root ganglion neurons [1].
We have now cloned the meleagrid (turkey) homologue of the previously cloned chick P2Y purinergic receptor and have stably expressed it in a heterologous human cell line (1321N1 astrocytoma cells) to establish its signaling properties [2].

High impact information on P2RY1

P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation [1].
A single cRNA derived from sensory neurons renders Xenopus laevis oocytes mechanosensitive and is found to encode a P2Y1 purinergic receptor [1].
The release of ATP into the extracellular space and the activation of peripheral P2Y1 receptors appear to participate in the generation of sensory action potentials by light touch [1].
In both rat and chick myotubes, P2Y1 and P2Y2 are expressed, increasing with differentiation, but P2Y4 is absent [3].
Purinergic receptor-mediated intracellular Ca2+ oscillations in chicken granulosa cells [4].

Biological context of P2RY1

Regional distribution of [35S]2'-deoxy 5'-O-(1-thio) ATP binding sites and the P2Y1 messenger RNA within the chick brain [5].

Anatomical context of P2RY1

We have previously used [35S]2'-deoxy 5'-O-(1-thio) ATP as a radioligand for the recombinant P2Y1 receptor transiently expressed in COS-7 cells and have also shown that such sites are present at high density (Bmax: approximately 37 pmol radioligand bound/mg protein) in chick brain membranes [5].

Associations of P2RY1 with chemical compounds

Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor [6].
In addition, the response was completely abolished by two specific P2Y1 receptor antagonists, namely, MRS 2179 (300 nM) and A3P5PS (10 microM) [7].
When a recombinant P2Y1 purinoceptor (derived from chick brain) is expressed in Xenopus oocytes, ATP and 2-methylthioATP (2-MeSATP) evoke calcium-activated chloride currents (ICl,Ca) in a concentration-dependent manner [6].

Other interactions of P2RY1

Identification of 6H1 as a P2Y purinoceptor: P2Y5 [8].

Analytical, diagnostic and therapeutic context of P2RY1

In parallel experiments, the regional and cellular localization of the P2Y1 receptor messenger RNA was examined by in situ hybridization [5].

References

P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Nakamura, F., Strittmatter, S.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. Filtz, T.M., Li, Q., Boyer, J.L., Nicholas, R.A., Harden, T.K. Mol. Pharmacol. (1994) [Pubmed]
P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Tung, E.K., Choi, R.C., Siow, N.L., Jiang, J.X., Ling, K.K., Simon, J., Barnard, E.A., Tsim, K.W. Mol. Pharmacol. (2004) [Pubmed]
Purinergic receptor-mediated intracellular Ca2+ oscillations in chicken granulosa cells. Morley, P., Vanderhyden, B.C., Tremblay, R., Mealing, G.A., Durkin, J.P., Whitfield, J.F. Endocrinology (1994) [Pubmed]
Regional distribution of [35S]2'-deoxy 5'-O-(1-thio) ATP binding sites and the P2Y1 messenger RNA within the chick brain. Webb, T.E., Simon, J., Barnard, E.A. Neuroscience (1998) [Pubmed]
Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. King, B.F., Dacquet, C., Ziganshin, A.U., Weetman, D.F., Burnstock, G., Vanhoutte, P.M., Spedding, M. Br. J. Pharmacol. (1996) [Pubmed]
Neurally released ATP mediates endothelium-dependent hyperpolarization in the circular smooth muscle cells of chicken anterior mesenteric artery. Draid, M., Shiina, T., El-Mahmoudy, A., Boudaka, A., Shimizu, Y., Takewaki, T. Br. J. Pharmacol. (2005) [Pubmed]
Identification of 6H1 as a P2Y purinoceptor: P2Y5. Webb, T.E., Kaplan, M.G., Barnard, E.A. Biochem. Biophys. Res. Commun. (1996) [Pubmed]

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P2RY1	Bos taurus
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p2ry1	Xenopus (Silurana) tropicalis

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