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Gene Review:

gnu - giant nuclei

Drosophila melanogaster

Synonyms: CG5272, Dmel\CG5272, Gnu

Zhang, X.H. et al., Renault, A.D. et al., Freeman, M. et al.

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High impact information on gnu

Giant nuclei originate from the products of female meiosis, and we see autonomously replicating centrosomes that must be maternally derived [1].
Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation [2].
giant nuclei is essential in the cell cycle transition from meiosis to mitosis [2].
Embryos containing pronounced anterior-posterior gradients of Gnu activity demonstrate that Gnu regulates mitotic activity by promoting cyclin B stability [3].
Spatial and temporal control of mitotic cyclins by the Gnu regulator of embryonic mitosis in Drosophila [3].

Anatomical context of gnu

The Gnu phosphoprotein is normally synthesized in nurse cells and transported to the developing oocyte [3].

References

The gnu mutation of Drosophila causes inappropriate DNA synthesis in unfertilized and fertilized eggs. Freeman, M., Glover, D.M. Genes Dev. (1987) [Pubmed]
giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Renault, A.D., Zhang, X.H., Alphey, L.S., Frenz, L.M., Glover, D.M., Saunders, R.D., Axton, J.M. Development (2003) [Pubmed]
Spatial and temporal control of mitotic cyclins by the Gnu regulator of embryonic mitosis in Drosophila. Zhang, X.H., Axton, J.M., Drinjákovic, J., Lorenz, L., White-Cooper, H., Renault, A.D. J. Cell. Sci. (2004) [Pubmed]

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