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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KCNJ3  -  potassium inwardly-rectifying channel,...

Gallus gallus

 
 
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Disease relevance of KCNJ3

  • In Xenopus laetis oocytes co-expression of GIRK1 with either the chick M2 or M4 mAChR gave carbamylcholine (10 microm)-stimulated K+ currents of 308 +/-26 nA and 298 +/-29 nA, respectively, which were both Ba2+- and pertussis toxin-sensitive [1].
 

High impact information on KCNJ3

  • We have demonstrated previously that induction of endogenous cholesterol synthesis in cultured cardiac myocytes resulted in a coordinated increase in expression of muscarinic receptors, the G protein alpha-subunit, G-alphai2, and the inward rectifying K+ channel, GIRK1 [2].
  • In this study we determined the specificity of coupling of the M3 and M4 mAChR to a new GIRK1 cloned from a chick brain cDNA library [1].
  • This clone codes for a 492-amino acid protein that is 93% identical to rat GIRK1 and is expressed in brain, atrium, and ventricle, but not skeletal muscle [1].

References

  1. Specificity of coupling of muscarinic receptor isoforms to a novel chick inward-rectifying acetylcholine-sensitive K+ channel. Gadbut, A.P., Riccardi, D., Wu, L., Hebert, S.C., Galper, J.B. J. Biol. Chem. (1996) [Pubmed]
  2. Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. Gadbut, A.P., Wu, L., Tang, D., Papageorge, A., Watson, J.A., Galper, J.B. EMBO J. (1997) [Pubmed]
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