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Gene Review:

TGM2 - transglutaminase 2 (C polypeptide, protein...

Gallus gallus

Thomázy, V.A. et al., Hand, D. et al., Lu, X. et al., Groenen, P.J. et al., Schneider, M.D. et al.

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High impact information on TGM2

Cell death was characterized by morphological changes, the induction of tissue transglutaminase, and autodigestion of DNA [1].
An apparently constitutive expression of tissue transglutaminase was found in vascular endothelial cells corresponding to the adult expression pattern [2].
Expression of tissue transglutaminase in the developing chicken limb is associated both with apoptosis and endochondral ossification [2].
Tissue transglutaminase expression was observed in developmentally transient structures in embryonic chicken limb at day 7.5 of incubation suggesting that its expression is dynamically regulated during limb morphogenesis [2].
The carboxy-terminal lysine of alpha B-crystallin is an amine-donor substrate for tissue transglutaminase [3].

Anatomical context of TGM2

We have investigated whether this insoluble pool forms through covalent cross-linking of A-AChE to extracellular matrix glycoproteins by tissue transglutaminase (Tg; type 2 transglutaminase) [4].

Analytical, diagnostic and therapeutic context of TGM2

To assess its contribution to extracellular and intracellular processes during development we cloned the cDNA for chicken heart tissue transglutaminase and localized the sites of transglutaminase expression by in situ hybridization and immunohistochemistry [2].
Localization of TGM-2 to the carboxy-terminus of S-2 was substantiated by immunoelectron microscopy [5].

References

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Lu, X., Xie, W., Reed, D., Bradshaw, W.S., Simmons, D.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Expression of tissue transglutaminase in the developing chicken limb is associated both with apoptosis and endochondral ossification. Thomázy, V.A., Davies, P.J. Cell Death Differ. (1999) [Pubmed]
The carboxy-terminal lysine of alpha B-crystallin is an amine-donor substrate for tissue transglutaminase. Groenen, P.J., Bloemendal, H., de Jong, W.W. Eur. J. Biochem. (1992) [Pubmed]
Stabilization of collagen-tailed acetylcholinesterase in muscle cells through extracellular anchorage by transglutaminase-catalyzed cross-linking. Hand, D., Dias, D., Haynes, L.W. Mol. Cell. Biochem. (2000) [Pubmed]
Localization and topography of antigenic domains within the heavy chain of smooth muscle myosin. Schneider, M.D., Sellers, J.R., Vahey, M., Preston, Y.A., Adelstein, R.S. J. Cell Biol. (1985) [Pubmed]

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