Gene Review:
TGM2 - transglutaminase 2
Homo sapiens
Synonyms:
G-ALPHA-h, GNAH, HEL-S-45, Protein-glutamine gamma-glutamyltransferase 2, TG(C), ...
- Transglutaminase 2: an enigmatic enzyme with diverse functions. Fesus, L., Piacentini, M. Trends Biochem. Sci. (2002)
- Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis. Piredda, L., Farrace, M.G., Lo Bello, M., Malorni, W., Melino, G., Petruzzelli, R., Piacentini, M. FASEB J. (1999)
- Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. Greenberg, C.S., Birckbichler, P.J., Rice, R.H. FASEB J. (1991)
- Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process. Fleckenstein, B., Molberg, Ø., Qiao, S.W., Schmid, D.G., von der Mülbe, F., Elgstøen, K., Jung, G., Sollid, L.M. J. Biol. Chem. (2002)
- Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. Belkin, A.M., Akimov, S.S., Zaritskaya, L.S., Ratnikov, B.I., Deryugina, E.I., Strongin, A.Y. J. Biol. Chem. (2001)
- Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease. Citron, B.A., SantaCruz, K.S., Davies, P.J., Festoff, B.W. J. Biol. Chem. (2001)
- Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases. Bailey, C.D., Graham, R.M., Nanda, N., Davies, P.J., Johnson, G.V. Mol. Cell. Neurosci. (2004)
- Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies. Junn, E., Ronchetti, R.D., Quezado, M.M., Kim, S.Y., Mouradian, M.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Cerebrospinal fluid tissue transglutaminase in vascular dementia. Bonelli, R.M., Aschoff, A., Jirikowski, G. J. Neurol. Sci. (2002)
- Molecular basis of celiac disease. Sollid, L.M. Annu. Rev. Immunol. (2000)
- Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surface. Csosz, E., Meskó, B., Fésüs, L. Amino. Acids. (2009)
- In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Anderson, R.P., Degano, P., Godkin, A.J., Jewell, D.P., Hill, A.V. Nat. Med. (2000)
- Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Molberg, O., Mcadam, S.N., Körner, R., Quarsten, H., Kristiansen, C., Madsen, L., Fugger, L., Scott, H., Norén, O., Roepstorff, P., Lundin, K.E., Sjöström, H., Sollid, L.M. Nat. Med. (1998)
- Identification of tissue transglutaminase as the autoantigen of celiac disease. Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E.O., Schuppan, D. Nat. Med. (1997)
- Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. Tucholski, J., Johnson, G.V. J. Biol. Chem. (2003)
- The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells. Beck, K.E., De Girolamo, L.A., Griffin, M., Billett, E.E. Neurosci. Lett. (2006)
- Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells. Antonyak, M.A., Miller, A.M., Jansen, J.M., Boehm, J.E., Balkman, C.E., Wakshlag, J.J., Page, R.L., Cerione, R.A. J. Biol. Chem. (2004)
- Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis. Palosuo, K., Varjonen, E., Nurkkala, J., Kalkkinen, N., Harvima, R., Reunala, T., Alenius, H. J. Allergy Clin. Immunol. (2003)
- Immunohistochemical evaluation of transglutaminase C in tumours of salivary glands. Lee, C.H., Lee, S.K., Chi, J.G., Park, S.C., Chung, S.I., Saitoh, M., Shrestha, P., Mori, M. Eur. J. Cancer, B, Oral Oncol. (1996)
- Structure and organization of the human transglutaminase 3 gene: evolutionary relationship to the transglutaminase family. Kim, I.G., Lee, S.C., Lee, J.H., Yang, J.M., Chung, S.I., Steinert, P.M. J. Invest. Dermatol. (1994)
- Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2. Wang, M., Kim, I.G., Steinert, P.M., McBride, O.W. Genomics (1994)
- Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2). Nanda, N., Iismaa, S.E., Copeland, N.G., Gilbert, D.J., Jenkins, N., Graham, R.M., Sutrave, P. Arch. Biochem. Biophys. (1999)
- Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. Akimov, S.S., Krylov, D., Fleischman, L.F., Belkin, A.M. J. Cell Biol. (2000)
- External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. Johnson, K.A., Terkeltaub, R.A. J. Biol. Chem. (2005)
- Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates. Chun, W., Lesort, M., Tucholski, J., Ross, C.A., Johnson, G.V. J. Cell Biol. (2001)
- Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Liu, S., Cerione, R.A., Clardy, J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Modulation of the in situ activity of tissue transglutaminase by calcium and GTP. Zhang, J., Lesort, M., Guttmann, R.P., Johnson, G.V. J. Biol. Chem. (1998)
- Tissue transglutaminase is essential for integrin-mediated survival of bone marrow-derived mesenchymal stem cells. Song, H., Chang, W., Lim, S., Seo, H.S., Shim, C.Y., Park, S., Yoo, K.J., Kim, B.S., Min, B.H., Lee, H., Jang, Y., Chung, N., Hwang, K.C. Stem. Cells (2007)
- Substrate preference of transglutaminase 2 revealed by logistic regression analysis and intrinsic disorder examination
WikiGenes . Article - Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells. Chun, W., Lesort, M., Tucholski, J., Faber, P.W., MacDonald, M.E., Ross, C.A., Johnson, G.V. Neurobiol. Dis. (2001)
- Involvement of tissue transglutaminase in the stabilisation of biomaterial/tissue interfaces important in medical devices. Heath, D.J., Christian, P., Griffin, M. Biomaterials (2002)
- Overexpression of transglutaminase 2 accelerates the erythroid differentiation of human chronic myelogenous leukemia K562 cell line through PI3K/Akt signaling pathway. Kang, S.K., Lee, J.Y., Chung, T.W., Kim, C.H. FEBS Lett. (2004)
- Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies. Korponay-Szabó, I.R., Sulkanen, S., Halttunen, T., Maurano, F., Rossi, M., Mazzarella, G., Laurila, K., Troncone, R., Mäki, M. J. Pediatr. Gastroenterol. Nutr. (2000)
- Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): Proposed mechanism for modulation of endothelial cell response to VEGF. Dardik, R., Inbal, A. Exp. Cell Res. (2006)
- Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP. Lai, T.S., Slaughter, T.F., Peoples, K.A., Hettasch, J.M., Greenberg, C.S. J. Biol. Chem. (1998)
- Phosphorylation of histones by tissue transglutaminase. Mishra, S., Saleh, A., Espino, P.S., Davie, J.R., Murphy, L.J. J. Biol. Chem. (2006)
- Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease. Andringa, G., Lam, K.Y., Chegary, M., Wang, X., Chase, T.N., Bennett, M.C. FASEB J. (2004)
- Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability. Sumi, Y., Inoue, N., Azumi, H., Seno, T., Okuda, M., Hirata, K., Kawashima, S., Hayashi, Y., Itoh, H., Yokoyama, M. Atherosclerosis (2002)
- Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Ibanez de Caceres, I., Dulaimi, E., Hoffman, A.M., Al-Saleem, T., Uzzo, R.G., Cairns, P. Cancer Res. (2006)
- TGF-beta2-induced cell surface tissue transglutaminase increases adhesion and migration of RPE cells on fibronectin through the gelatin-binding domain. Priglinger, S.G., Alge, C.S., Neubauer, A.S., Kristin, N., Hirneiss, C., Eibl, K., Kampik, A., Welge-Lussen, U. Invest. Ophthalmol. Vis. Sci. (2004)
- Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity. Satpathy, M., Shao, M., Emerson, R., Donner, D.B., Matei, D. J. Biol. Chem. (2009)
- The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity. Mishra, S., Murphy, L.J. Biochem. Biophys. Res. Commun. (2006)
- Transforming growth factor-beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease. Hansson, T., Ulfgren, A.K., Lindroos, E., DannAEus, A., Dahlbom, I., Klareskog, L. Scand. J. Immunol. (2002)
- Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase. Guyot, N., Zani, M.L., Maurel, M.C., Dallet-Choisy, S., Moreau, T. Biochemistry (2005)
- Characterization of tissue transglutaminase in human osteoblast-like cells. Heath, D.J., Downes, S., Verderio, E., Griffin, M. J. Bone Miner. Res. (2001)
- Differential expression of multiple transglutaminases in human colon: impaired keratinocyte transglutaminase expression in ulcerative colitis. D'Argenio, G., Calvani, M., Della Valle, N., Cosenza, V., Di Matteo, G., Giorgio, P., Margarucci, S., Petillo, O., Jori, F.P., Galderisi, U., Peluso, G. Gut (2005)