The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tgm2  -  transglutaminase 2, C polypeptide

Mus musculus

Synonyms: G[a]h, Protein-glutamine gamma-glutamyltransferase 2, TG C, TG(C), TG2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tgm2


Psychiatry related information on Tgm2


High impact information on Tgm2


Biological context of Tgm2


Anatomical context of Tgm2


Associations of Tgm2 with chemical compounds


Physical interactions of Tgm2


Enzymatic interactions of Tgm2


Co-localisations of Tgm2


Regulatory relationships of Tgm2


Other interactions of Tgm2

  • The purpose of this study was to investigate the relationship between the occurrence of apoptosis in the mouse limb during normal and abnormal development as well as the expression of tissue transglutaminase and clusterin, two proteins associated with apoptotic cell death [20].
  • Experiments with deletion mutants of the first domain revealed that amino acids 81-140 of tissue transglutaminase are involved in fibronectin binding [13].
  • Analysis of Ras/Raf downstream signaling with specific pharmacological inhibitors reveals that the decrease in tTG expression is mediated by the p38 MAPK, c-Jun NH2-terminal kinase, and phosphatidylinositol 3-kinase pathways [14].
  • Substitution of individual domains of tissue transglutaminase with those from homologous factor XIIIA showed that the major fibronectin-binding site is present within the first beta-sandwich domain of the protein [13].
  • In this second model of cell wounding, redistribution of tTG activity to the extracellular matrix was also demonstrated, an effect which may serve to stabilize tissues post-trauma, and thus contribute to the maintenance of tissue integrity [24].

Analytical, diagnostic and therapeutic context of Tgm2


  1. Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. Bailey, C.D., Johnson, G.V. J. Neurochem. (2005) [Pubmed]
  2. Tetanus toxin potently stimulates tissue transglutaminase. A possible mechanism of neurotoxicity. Facchiano, F., Luini, A. J. Biol. Chem. (1992) [Pubmed]
  3. Suppression of macrophage cytostatic activation by serum retinoids: a possible role for transglutaminase. Mehta, K., Claringbold, P., Lopez-Berestein, G. J. Immunol. (1987) [Pubmed]
  4. Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Yuan, L., Choi, K., Khosla, C., Zheng, X., Higashikubo, R., Chicoine, M.R., Rich, K.M. Mol. Cancer Ther. (2005) [Pubmed]
  5. Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion. Andreola, F., Calvisi, D.F., Elizondo, G., Jakowlew, S.B., Mariano, J., Gonzalez, F.J., De Luca, L.M. Hepatology (2004) [Pubmed]
  6. The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase. Bailey, C.D., Johnson, G.V. Neurobiol. Aging (2006) [Pubmed]
  7. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alfos, S., Boucheron, C., Pallet, V., Higueret, D., Enderlin, V., Béracochéa, D., Jaffard, R., Higueret, P. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  8. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K.L., Korponay-Szabó, I.R., Sarnesto, A., Savilahti, E., Collin, P., Mäki, M. Gastroenterology (1998) [Pubmed]
  9. Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion. Gentile, V., Thomazy, V., Piacentini, M., Fesus, L., Davies, P.J. J. Cell Biol. (1992) [Pubmed]
  10. Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Szondy, Z., Sarang, Z., Molnar, P., Nemeth, T., Piacentini, M., Mastroberardino, P.G., Falasca, L., Aeschlimann, D., Kovacs, J., Kiss, I., Szegezdi, E., Lakos, G., Rajnavolgyi, E., Birckbichler, P.J., Melino, G., Fesus, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Fetal mouse selenophosphate synthetase 2 (SPS2): characterization of the cysteine mutant form overproduced in a baculovirus-insect cell system. Kim, I.Y., Guimarães, M.J., Zlotnik, A., Bazan, J.F., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid-regulated and apoptosis-linked expression. Nagy, L., Thomázy, V.A., Saydak, M.M., Stein, J.P., Davies, P.J. Cell Death Differ. (1997) [Pubmed]
  13. Identification of a novel recognition sequence for fibronectin within the NH2-terminal beta-sandwich domain of tissue transglutaminase. Hang, J., Zemskov, E.A., Lorand, L., Belkin, A.M. J. Biol. Chem. (2005) [Pubmed]
  14. Opposing roles of Ras/Raf oncogenes and the MEK1/ERK signaling module in regulation of expression and adhesive function of surface transglutaminase. Akimov, S.S., Belkin, A.M. J. Biol. Chem. (2003) [Pubmed]
  15. Developmental regulation of tissue transglutaminase in the mouse forebrain. Bailey, C.D., Johnson, G.V. J. Neurochem. (2004) [Pubmed]
  16. Regulation of the dual function tissue transglutaminase/Galpha(h) during murine neuromuscular development: gene and enzyme isoform expression. Citron, B.A., Gregory, E.J., Steigerwalt, D.S., Qin, F., Festoff, B.W. Neurochem. Int. (2000) [Pubmed]
  17. Targeted inactivation of Gh/tissue transglutaminase II. Nanda, N., Iismaa, S.E., Owens, W.A., Husain, A., Mackay, F., Graham, R.M. J. Biol. Chem. (2001) [Pubmed]
  18. Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice. Sarang, Z., Molnár, P., Németh, T., Gomba, S., Kardon, T., Melino, G., Cotecchia, S., Fésüs, L., Szondy, Z. Hepatology (2005) [Pubmed]
  19. Gene disruption of tissue transglutaminase. De Laurenzi, V., Melino, G. Mol. Cell. Biol. (2001) [Pubmed]
  20. Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse. Adel Moallem, S., Hales, B.F. Biol. Reprod. (1996) [Pubmed]
  21. Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain. Gaudry, C.A., Verderio, E., Aeschlimann, D., Cox, A., Smith, C., Griffin, M. J. Biol. Chem. (1999) [Pubmed]
  22. Lack of induction of tissue transglutaminase but activation of the preexisting enzyme in c-Myc-induced apoptosis of CHO cells. Balajthy, Z., Kedei, N., Nagy, L., Davies, P.J., Fésüs, L. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  23. Tissue transglutaminase triggers oligomerization and activation of dual leucine zipper-bearing kinase in calphostin C-treated cells to facilitate apoptosis. Robitaille, K., Daviau, A., Tucholski, J., Johnson, G.V., Rancourt, C., Blouin, R. Cell Death Differ. (2004) [Pubmed]
  24. Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death: a mechanism for maintaining tissue integrity. Nicholas, B., Smethurst, P., Verderio, E., Jones, R., Griffin, M. Biochem. J. (2003) [Pubmed]
  25. Arachidonic acid activates tissue transglutaminase and stress fiber formation via intracellular reactive oxygen species. Yi, S.J., Choi, H.J., Yoo, J.O., Yuk, J.S., Jung, H.I., Lee, S.H., Han, J.A., Kim, Y.M., Ha, K.S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  26. Differential expression of tissue transglutaminase protein in mouse ovarian follicle. Lee, C.J., Do, B.R., Lee, J.M., Song, K.W., Kang, J.S., Park, M.H. In Vivo (2003) [Pubmed]
WikiGenes - Universities