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Gene Review:

SREBP-1 - sterol regulatory element binding protein 1

Sus scrofa

Louveau, I. et al., Ruiz-Cortés, Z.T. et al., Sekar, N. et al., Rodríguez, C. et al., Rodriguez, C. et al.

Louveau, Gondret,

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High impact information on SREBP-1

LH alone augmented stimulation by SREBP-1 twofold [1].
To assess the role of SRE-binding protein (SREBP) in LDLR gene regulation, swine granulosa-luteal cells were cotransfected with CMV/SREBP-1a or SREBP-2 and the pLDLR1076/luc promoter [1].
Leptin at 1000 ng/ml inhibited SREBP1-induced StAR expression [2].
StAR transcription was also increased by the low dose of leptin and was further upregulated in the presence of the SREBP plasmid [2].
The present study aimed to determine whether the regulation of lipogenesis by GH and/or insulin in porcine adipocytes also involved SREBP-1 [3].

Anatomical context of SREBP-1

Expression of the transcription factor sterol regulatory element binding protein (SREBP)-1 has been reported as a key mediator of insulin action in rat hepatocytes and adipose cell lines [3].

Physical interactions of SREBP-1

Leptin had a biphasic effect on the abundance of membrane-bound and transcriptionally active forms of SREBP1 [2].

Other interactions of SREBP-1

In parallel, sterol regulatory element (SRE) binding protein-2 (SREBP-2) expression falls (10-fold), without alteration in SREBP-1 level [4].
GH and insulin affect fatty acid synthase activity in isolated porcine adipocytes in culture without any modifications of sterol regulatory element binding protein-1 expression [3].

Analytical, diagnostic and therapeutic context of SREBP-1

SREBP-1 protein levels were assessed by Western blot and SREBP-SRE binding by EMSA [5].

References

Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells. Sekar, N., Veldhuis, J.D. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
Biphasic effects of leptin in porcine granulosa cells. Ruiz-Cortés, Z.T., Martel-Kennes, Y., Gévry, N.Y., Downey, B.R., Palin, M.F., Murphy, B.D. Biol. Reprod. (2003) [Pubmed]
GH and insulin affect fatty acid synthase activity in isolated porcine adipocytes in culture without any modifications of sterol regulatory element binding protein-1 expression. Louveau, I., Gondret, F. J. Endocrinol. (2004) [Pubmed]
LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism. Rodríguez, C., Martínez-González, J., Sánchez-Gómez, S., Badimon, L. Circ. Res. (2001) [Pubmed]
Modulation of ERG25 expression by LDL in vascular cells. Rodriguez, C., Raposo, B., Martínez-González, J., Llorente-Cortés, V., Vilahur, G., Badimon, L. Cardiovasc. Res. (2003) [Pubmed]

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