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SREBP-1  -  sterol regulatory element binding protein 1

Sus scrofa

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High impact information on SREBP-1


Anatomical context of SREBP-1


Physical interactions of SREBP-1

  • Leptin had a biphasic effect on the abundance of membrane-bound and transcriptionally active forms of SREBP1 [2].

Other interactions of SREBP-1


Analytical, diagnostic and therapeutic context of SREBP-1

  • SREBP-1 protein levels were assessed by Western blot and SREBP-SRE binding by EMSA [5].


  1. Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells. Sekar, N., Veldhuis, J.D. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  2. Biphasic effects of leptin in porcine granulosa cells. Ruiz-Cortés, Z.T., Martel-Kennes, Y., Gévry, N.Y., Downey, B.R., Palin, M.F., Murphy, B.D. Biol. Reprod. (2003) [Pubmed]
  3. GH and insulin affect fatty acid synthase activity in isolated porcine adipocytes in culture without any modifications of sterol regulatory element binding protein-1 expression. Louveau, I., Gondret, F. J. Endocrinol. (2004) [Pubmed]
  4. LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism. Rodríguez, C., Martínez-González, J., Sánchez-Gómez, S., Badimon, L. Circ. Res. (2001) [Pubmed]
  5. Modulation of ERG25 expression by LDL in vascular cells. Rodriguez, C., Raposo, B., Martínez-González, J., Llorente-Cortés, V., Vilahur, G., Badimon, L. Cardiovasc. Res. (2003) [Pubmed]
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