High impact information on PGK2

• There was a lower amount of PGK2 expression in the testis of a 10-month-old herniated boar and a very small amount of PGK2 expression in the testis of an 8-week-old cryptorchid piglet compared to an adult boar [1].
• Two SNPs in the PGK2 gene (SNP-A: T427C; SNP-B: C914A) resulting in amino acid substitutions (SNP-A: Ser102-Pro102; SNP-B: Thr264-Lys264) were detected and genotyped among six pig breeds [1].
• The nucleotide C at SNP-A responsible for the amino acid exchange to proline could lead to the loss of a casein kinase II (CK2) phosphorylation site in the PGK2 peptide [1].
• The results of genomic and cDNA sequences of the porcine PGK2 gene demonstrated that it is a single-exon intronless gene with a complete open reading frame of 1251 bp encoding a PGK protein of 417 amino acids [1].
• Association analyses between PGK2 genotypes and several traits of sperm quantity and quality were performed [1].

Biological context of PGK2

• Assignment of the phosphoglycerate kinase 2 (PGK2) gene to porcine chromosome 7q14-q15 by fluorescence in situ hybridization and by analysis of somatic cell and radiation hybrid panels [2].
• Characterization of the PGK2 associated microsatellite S0719 on SSC7 suitable for parentage and QTL diagnosis [3].

Anatomical context of PGK2

• Real-time quantitative PCR results showed that PGK2 mRNA was solely expressed in the testis [1].

References