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Gene Review:

NHE-2 - Na+/H+ exchanger isoform 2

Sus scrofa

This record was replaced with 100101921.

Singh, G. et al., Kuwahara, M. et al.

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High impact information on NHE-2

NHE-2 is predominantly expressed in the inner medulla whereas NHE-3 is highly expressed in the proximal tubule cells [1].
Transient expression of Na+/H+ exchanger isoform NHE-2 in LLC-PK1 cells: inhibition of endogenous NHE-3 and regulation by hypertonicity [1].
Na+/H+ exchanger isoforms NHE-2 and NHE-3 demonstrate distinct tissue expression patterns in renal epithelial cells [1].
The NHE-2 is stimulated by hypertonicity, indicating a likely role for this isoform in cell volume regulation [1].
At 60 hr after transfection, the cells exhibited PMA-stimulated Na influx (>28%) indicating functional expression of NHE-2 [1].

Anatomical context of NHE-2

These results suggest: (1) NHE-1 is distributed over the plasma membrane in early confluent LLC-PK1 monolayers; and (2) then, NHE-2 (inhibitor-resistant NHE) gradually begins to be expressed specifically in the apical membrane, and the distribution of NHE-1 becomes confined to basolateral membrane [2].

References

Transient expression of Na+/H+ exchanger isoform NHE-2 in LLC-PK1 cells: inhibition of endogenous NHE-3 and regulation by hypertonicity. Singh, G., Orlowski, J., Soleimani, M. J. Membr. Biol. (1996) [Pubmed]
Different development of apical and basolateral Na-H exchangers in LLC-PK1 renal epithelial cells: characterization by inhibitors and antisense oligonucleotide. Kuwahara, M., Sasaki, S., Uchida, S., Cragoe, E.J., Marumo, F. Biochim. Biophys. Acta (1994) [Pubmed]

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