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AMCF-II  -  alveolar macrophage-derived chemotactic...

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High impact information on AMCF-II

  • The second peptide, AMCF-II, was active at 1.4 x 10(-9) M for porcine neutrophils, but it was less active for human polymorphonuclear neutrophils than was AMCF-I [1].
  • Specific oligonucleotide probes for AMCF-I and AMCF-II were amplified from the porcine AM cDNA library by the polymerase chain reaction using degenerate oligonucleotide primer pairs derived from the N-terminal amino acid sequences of the proteins [2].
  • AMCF-II may represent a new member of the intercrine-alpha family of neutrophil chemoattractants.(ABSTRACT TRUNCATED AT 250 WORDS)[2]
  • These probes were used to isolate 2 full-length cDNAs of 1466 (AMCF-I) and 1515 (AMCF-II) base pairs [2].


  1. Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages. Goodman, R.B., Forstrom, J.W., Osborn, S.G., Chi, E.Y., Martin, T.R. J. Biol. Chem. (1991) [Pubmed]
  2. Molecular cloning of porcine alveolar macrophage-derived neutrophil chemotactic factors I and II; identification of porcine IL-8 and another intercrine-alpha protein. Goodman, R.B., Foster, D.C., Mathewes, S.L., Osborn, S.G., Kuijper, J.L., Forstrom, J.W., Martin, T.R. Biochemistry (1992) [Pubmed]
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