Gene Review:
CXCL8 - chemokine (C-X-C motif) ligand 8
Homo sapiens
Synonyms:
3-10C, AMCF-I, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, ...
Gendelman,
Zheng,
Sarau,
Inglese,
Wouters,
Winkelbauer,
Schnyder-Candrian,
Cao,
Dentener,
Widdowson,
Gunter,
Carlson,
Gorantla,
Hertzberg,
Manuck,
Appell,
Persidsky,
Samama,
Young,
Wu,
Schnyder,
Martin,
Marsland,
Chanock,
Küçükaycan,
Stroke,
Sinha,
Zhang,
Shen,
Chaikin,
Bogdan,
Moser,
Boyle,
Vernooy,
Jacobs,
Buurman,
Muldoon,
Jurewicz,
Zhang,
White,
Canzian,
Foley,
Sathanoori,
Ghorpade,
Dewald,
Burbaum,
Zhou,
Patel,
Lee,
Landi,
Griswold,
Xiong,
Baggiolini,
Chavannes,
Rothman,
- Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Campa, D., Zienolddiny, S., Maggini, V., Skaug, V., Haugen, A., Canzian, F. Carcinogenesis (2004)
- Inflammation-related gene polymorphisms and colorectal adenoma. Gunter, M.J., Canzian, F., Landi, S., Chanock, S.J., Sinha, R., Rothman, N. Cancer Epidemiol. Biomarkers Prev. (2006)
- Reversing systemic inflammatory response syndrome with chemokine receptor pepducins. Kaneider, N.C., Agarwal, A., Leger, A.J., Kuliopulos, A. Nat. Med. (2005)
- Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. Desbaillets, I., Diserens, A.C., Tribolet, N., Hamou, M.F., Van Meir, E.G. J. Exp. Med. (1997)
- Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer. Araki, S., Omori, Y., Lyn, D., Singh, R.K., Meinbach, D.M., Sandman, Y., Lokeshwar, V.B., Lokeshwar, B.L. Cancer Res. (2007)
- Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia. Xiong, H., Boyle, J., Winkelbauer, M., Gorantla, S., Zheng, J., Ghorpade, A., Persidsky, Y., Carlson, K.A., Gendelman, H.E. J. Neurosci. Res. (2003)
- Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Zhang, X.Y., Zhou, D.F., Zhang, P.Y., Wu, G.Y., Cao, L.Y., Shen, Y.C. Schizophr. Res. (2002)
- Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Vernooy, J.H., Küçükaycan, M., Jacobs, J.A., Chavannes, N.H., Buurman, W.A., Dentener, M.A., Wouters, E.F. Am. J. Respir. Crit. Care Med. (2002)
- Stimulated production of interleukin-8 covaries with psychosocial risk factors for inflammatory disease among middle-aged community volunteers. Marsland, A.L., Sathanoori, R., Muldoon, M.F., Manuck, S.B. Brain Behav. Immun. (2007)
- Regional cerebral blood flow and cytokines in young females with fibromyalgia. Gur, A., Karakoc, M., Erdogan, S., Nas, K., Cevik, R., Sarac, A.J. Clinical and experimental rheumatology. (2002)
- Human chemokines: an update. Baggiolini, M., Dewald, B., Moser, B. Annu. Rev. Immunol. (1997)
- The molecular biology of leukocyte chemoattractant receptors. Murphy, P.M. Annu. Rev. Immunol. (1994)
- Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., Ding, A. Cell (2002)
- Intrathecal methylprednisolone for intractable postherpetic neuralgia. Kotani, N., Kushikata, T., Hashimoto, H., Kimura, F., Muraoka, M., Yodono, M., Asai, M., Matsuki, A. N. Engl. J. Med. (2000)
- Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. Brandtzaeg, P., Osnes, L., Ovstebø, R., Joø, G.B., Westvik, A.B., Kierulf, P. J. Exp. Med. (1996)
- Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity. L'Heureux, G.P., Bourgoin, S., Jean, N., McColl, S.R., Naccache, P.H. Blood (1995)
- Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Amiral, J., Marfaing-Koka, A., Wolf, M., Alessi, M.C., Tardy, B., Boyer-Neumann, C., Vissac, A.M., Fressinaud, E., Poncz, M., Meyer, D. Blood (1996)
- Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. Mukaida, N., Morita, M., Ishikawa, Y., Rice, N., Okamoto, S., Kasahara, T., Matsushima, K. J. Biol. Chem. (1994)
- Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. Yasumoto, K., Okamoto, S., Mukaida, N., Murakami, S., Mai, M., Matsushima, K. J. Biol. Chem. (1992)
- Molecular evolution of the human interleukin-8 receptor gene cluster. Ahuja, S.K., Ozçelik, T., Milatovitch, A., Francke, U., Murphy, P.M. Nat. Genet. (1992)
- Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. Cassatella, M.A., Meda, L., Bonora, S., Ceska, M., Constantin, G. J. Exp. Med. (1993)
- Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E., Kung, H.F., Leonard, E.J., Oppenheim, J.J. J. Exp. Med. (1988)
- Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. Walz, A., Dewald, B., von Tscharner, V., Baggiolini, M. J. Exp. Med. (1989)
- Activation of CD38 by interleukin-8 signaling regulates intracellular Ca2+ level and motility of lymphokine-activated killer cells. Rah, S.Y., Park, K.H., Han, M.K., Im, M.J., Kim, U.H. J. Biol. Chem. (2005)
- The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. Van Damme, J., Rampart, M., Conings, R., Decock, B., Van Osselaer, N., Willems, J., Billiau, A. Eur. J. Immunol. (1990)
- Normal breast epithelial cells produce interleukins 6 and 8 together with tumor-necrosis factor: defective IL6 expression in mammary carcinoma. Basolo, F., Conaldi, P.G., Fiore, L., Calvo, S., Toniolo, A. Int. J. Cancer (1993)
- Superinduction of interleukin 8 mRNA in activated monocyte derived macrophages from rheumatoid arthritis patients. Rodenburg, R.J., van Den Hoogen, F.H., Barrera, P., van Venrooij, W.J., van De Putte, L.B. Ann. Rheum. Dis. (1999)
- Chemokine receptor-ligand interactions measured using time-resolved fluorescence. Inglese, J., Samama, P., Patel, S., Burbaum, J., Stroke, I.L., Appell, K.C. Biochemistry (1998)
- Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. Schröder, J.M., Persoon, N.L., Christophers, E. J. Exp. Med. (1990)
- Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Joshi-Barve, S., Barve, S.S., Amancherla, K., Gobejishvili, L., Hill, D., Cave, M., Hote, P., McClain, C.J. Hepatology (2007)
- Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumor necrosis factor-alpha involves the transcription factor NF-kappaB. Harant, H., de Martin, R., Andrew, P.J., Foglar, E., Dittrich, C., Lindley, I.J. J. Biol. Chem. (1996)
- Melanoma growth-stimulatory activity/GRO decreases collagen expression by human fibroblasts. Regulation by C-X-C but not C-C cytokines. Unemori, E.N., Amento, E.P., Bauer, E.A., Horuk, R. J. Biol. Chem. (1993)
- A molecular switch of chemokine receptor selectivity. Chemical modification of the interleukin-8 Leu25 --> Cys mutant. Lusti-Narasimhan, M., Chollet, A., Power, C.A., Allet, B., Proudfoot, A.E., Wells, T.N. J. Biol. Chem. (1996)
- Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. White, J.R., Lee, J.M., Young, P.R., Hertzberg, R.P., Jurewicz, A.J., Chaikin, M.A., Widdowson, K., Foley, J.J., Martin, L.D., Griswold, D.E., Sarau, H.M. J. Biol. Chem. (1998)
- The human erythrocyte inflammatory peptide (chemokine) receptor. Biochemical characterization, solubilization, and development of a binding assay for the soluble receptor. Horuk, R., Colby, T.J., Darbonne, W.C., Schall, T.J., Neote, K. Biochemistry (1993)
- Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies. Bierings, R., van den Biggelaar, M., Kragt, A., Mertens, K., Voorberg, J., van Mourik, J.A. J. Thromb. Haemost. (2007)
- The differential ability of IL-8 and neutrophil-activating peptide-2 to induce attenuation of chemotaxis is mediated by their divergent capabilities to phosphorylate CXCR2 (IL-8 receptor B). Ben-Baruch, A., Grimm, M., Bengali, K., Evans, G.A., Chertov, O., Wang, J.M., Howard, O.M., Mukaida, N., Matsushima, K., Oppenheim, J.J. J. Immunol. (1997)
- Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-kappaB. Fritz, E.A., Jacobs, J.J., Glant, T.T., Roebuck, K.A. J. Orthop. Res. (2005)
- Novel pathways of F-actin polymerization in the human neutrophil. Chodniewicz, D., Zhelev, D.V. Blood (2003)
- Role of interleukin-8 phosphorylated kinases in stimulating neutrophil migration through fibrin gels. Schnyder, B., Bogdan, J.A., Schnyder-Candrian, S. Lab. Invest. (1999)
- Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells. Kimata, H., Yoshida, A., Ishioka, C., Lindley, I., Mikawa, H. J. Exp. Med. (1992)
- Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. Puren, A.J., Fantuzzi, G., Gu, Y., Su, M.S., Dinarello, C.A. J. Clin. Invest. (1998)
- Interleukin 18 stimulates HIV type 1 in monocytic cells. Shapiro, L., Puren, A.J., Barton, H.A., Novick, D., Peskind, R.L., Shenkar, R., Gu, Y., Su, M.S., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Interleukin-10 inhibits interleukin-8 production in human neutrophils. Wang, P., Wu, P., Anthes, J.C., Siegel, M.I., Egan, R.W., Billah, M.M. Blood (1994)
- Effect of granulocyte-macrophage colony-stimulating factor and interleukin-3 on interleukin-8 production by human neutrophils and monocytes. Takahashi, G.W., Andrews, D.F., Lilly, M.B., Singer, J.W., Alderson, M.R. Blood (1993)
- Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo. Gharavi, N.M., Alva, J.A., Mouillesseaux, K.P., Lai, C., Yeh, M., Yeung, W., Johnson, J., Szeto, W.L., Hong, L., Fishbein, M., Wei, L., Pfeffer, L.M., Berliner, J.A. J. Biol. Chem. (2007)
- Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8. Fernandes, A.F., Zhou, J., Zhang, X., Bian, Q., Sparrow, J., Taylor, A., Pereira, P., Shang, F. J. Biol. Chem. (2008)
- A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. Lüttichau, H.R., Stine, J., Boesen, T.P., Johnsen, A.H., Chantry, D., Gerstoft, J., Schwartz, T.W. J. Exp. Med. (2000)
- Immunoregulatory role of interleukin 10 in rheumatoid arthritis. Katsikis, P.D., Chu, C.Q., Brennan, F.M., Maini, R.N., Feldmann, M. J. Exp. Med. (1994)
- Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components. Zhang, Y., Broser, M., Cohen, H., Bodkin, M., Law, K., Reibman, J., Rom, W.N. J. Clin. Invest. (1995)
- Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Eckmann, L., Jung, H.C., Schürer-Maly, C., Panja, A., Morzycka-Wroblewska, E., Kagnoff, M.F. Gastroenterology (1993)