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Gene Review:

PLAT - plasminogen activator, tissue

Sus scrofa

Boldogköi, Z. et al., Soeda, S. et al., Boldogköi, Z. et al.

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High impact information on PLAT

A putative latency promoter (PLAT) located at the inverted repeat region of the PrV genome was chosen as the target site for the insertion [1].
As a first step, we engineered a unique EcoRI recognition site into the rr gene or into both copies of PLAT with the help of marker transfer using the bacterial lacZ gene [2].
To demonstrate, we introduced the tumour suppressor protein-53 (p53) gene into two different intergenic locations of PrV: the ribonucleotide reductase (rr) gene and the promoter of a putative latency gene (PLAT), located at the inverted repeat (IR) region of the viral genome [2].
To localize the binding region of porcine tissue-type plasminogen activator (EC 3.4.21.31) (t-plasminogen activator) to heparin, functionally active A and B chains (molecular mass of each 33 kDa) were separated from the two-chain t-plasminogen activator after mild reduction and alkylation [3].

References

Construction of a recombinant herpesvirus expressing the jellyfish green fluorescent protein. Boldogköi, Z., Erdélyi, F., Sik, A., Freund, T.F., Fodor, I. Luminescence : the journal of biological and chemical luminescence. (1999) [Pubmed]
A restriction cleavage and transfection system for introducing foreign DNA sequences into the genome of a herpesvirus. Boldogköi, Z., Braun, A., Antal, J., Fodor, I. Res. Virol. (1998) [Pubmed]
Localization of the binding sites of porcine tissue-type plasminogen activator and plasminogen to heparin. Soeda, S., Kakiki, M., Shimeno, H., Nagamatsu, A. Biochim. Biophys. Acta (1987) [Pubmed]

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