Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

JAK1 - Janus kinase 1

Sus scrofa

Leven, R.M. et al., Kuiper, H. et al.

Leven, Clark, Tablin,

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High impact information on JAK1

Adhesion of megakaryocytes to collagen gel also inhibited phosphorylation of JAK1 and JAK2, while MAP kinase phosphorylation was unaffected [1].
Although IBMX stimulated proplatelet formation, it inhibited phosphorylation of JAK1 and MAP kinase [1].
In addition, although these cytokines increase phosphorylation of signal transduction proteins in the JAK/STAT pathway, it appears that a different signal transduction pathway regulated by a combination of phosphatase activity and cAMP levels, leads to proplatelet formation [1].
Assignment of the porcine janus kinase 1 gene (JAK1) to chromosome 6q34-->q35 by fluorescence in situ hybridization and radiation hybrid mapping [2].

References

Effect of recombinant interleukin-6 and thrombopoietin on isolated guinea pig bone marrow megakaryocyte protein phosphorylation and proplatelet formation. Leven, R.M., Clark, B., Tablin, F. Blood Cells Mol. Dis. (1997) [Pubmed]
Assignment of the porcine janus kinase 1 gene (JAK1) to chromosome 6q34-->q35 by fluorescence in situ hybridization and radiation hybrid mapping. Kuiper, H., Martins-Wess, F., Lassnig, C., Distl, O., Müller, M., Leeb, T. Cytogenet. Genome Res. (2003) [Pubmed]

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