Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

JAK2 - Janus kinase 2

Sus scrofa

Liao, Z.Y. et al., Leven, R.M. et al., Wang, H. et al.

Leven, Clark, Tablin,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on JAK2

Mapping of the porcine JAK2, JAK3 and TYK2 genes using somatic cell and radiation hybrid panels [1].
Adhesion of megakaryocytes to collagen gel also inhibited phosphorylation of JAK1 and JAK2, while MAP kinase phosphorylation was unaffected [2].
It was found that the mutation of serine to tyrosine at position 332 greatly increased the GH-stimulated protein synthesis and the phosphorylation of JAK2, while the mutation of tyrosine to histidine at position 168 increased the protein synthesis and decreased the phosphorylation of JAK2 only weakly [3].
When CHO cells were transfected with the expression vectors, pcDNA3-gpGHR, pcDNA3-gpGHRY168H and pcDNA3-gpGHRS332Y, the gpGHR and its mutants were expressed and the ligand binding, phosphorylation of JAK2, protein synthesis, and lipogenesis were studied [3].

References

Mapping of the porcine JAK2, JAK3 and TYK2 genes using somatic cell and radiation hybrid panels. Wang, H., Yu, M., Liu, B., Yerle, M., Wang, Y., Fan, B., Zhu, Z., Zhu, M., Li, K. Anim. Genet. (2004) [Pubmed]
Effect of recombinant interleukin-6 and thrombopoietin on isolated guinea pig bone marrow megakaryocyte protein phosphorylation and proplatelet formation. Leven, R.M., Clark, B., Tablin, F. Blood Cells Mol. Dis. (1997) [Pubmed]
Functional expression of guinea pig growth hormone receptor and its mutants in mammalian cells. Liao, Z.Y., Zhang, X.N., Jing, N.H., Zhu, S.Q. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share