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CYCLT1  -  CysLT1 receptor

Sus scrofa

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High impact information on CYCLT1


Biological context of CYCLT1


Anatomical context of CYCLT1

  • The series contains several potent CysLT1 receptor antagonists, with K(D) values approaching the nanomolar range, as measured by the displacement of [3H]LTD4 from guinea pig lung membranes [4].


  1. Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. Zwaagstra, M.E., Timmerman, H., van de Stolpe, A.C., de Kanter, F.J., Tamura, M., Wada, Y., Zhang, M.Q. J. Med. Chem. (1998) [Pubmed]
  2. Comparative effects of a glucocorticosteroid, theophylline and the peptido-leukotriene-antagonist CGP 45715A on antigen-induced early and late phase airway response and inflammatory cell influx in sensitised guinea pigs. Heuer, H.O., Leon, I., Anderson, G.P., Jennewein, H.M. Eur. J. Pharmacol. (1999) [Pubmed]
  3. Agonist and antagonist activities of the leukotriene analogue BAY u9773 in guinea pig lung parenchyma. Wikström Jonsson, E., Rosenqvist, U., Dahlén, S.E. Eur. J. Pharmacol. (1998) [Pubmed]
  4. Synthesis and structure-activity relationships of carboxylated chalcones: a novel series of CysLT1 (LTD4) receptor antagonists. Zwaagstra, M.E., Timmerman, H., Tamura, M., Tohma, T., Wada, Y., Onogi, K., Zhang, M.Q. J. Med. Chem. (1997) [Pubmed]
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