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Gene Review:

IGF1R - insulin-like growth factor 1 receptor

Sus scrofa

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High impact information on IGF1R

Linkage and radiation hybrid mapping of the porcine IGF1R and TPM2 genes to chromosome 1 [1].
The sequence of a 4.2-kb product was determined and had an open reading frame, encoding 1367 amino acids with 98.1 and 95.2% sequence similarity to the human and rat IGF1R, respectively [2].
The genes coding for the insulin-like growth factor-1 receptor (IGF1R) and a porcine endothelium-derived 21-residue vasoconstrictor peptide (EDN) were localized in the pig by means of radioactive in situ hybridization [3].
Higher magnification revealed that IGF1R, IGFBP-3 and probably IGF-I appeared in the tubular system [4].

Analytical, diagnostic and therapeutic context of IGF1R

In the comparison of RT-PCR derived IGF1R sequences from 12 unrelated pigs, 12 silent sequence variants were found [2].

References

Linkage and radiation hybrid mapping of the porcine IGF1R and TPM2 genes to chromosome 1. Kopecný, M., Stratil, A., Bartenschlager, H., Peelman, L.J., Van Poucke, M., Geldermann, H. Anim. Genet. (2002) [Pubmed]
Cloning of porcine IGF1 receptor cDNA and detection of sequence polymorphisms using RT-PCR. Harumi, T., Maruyama, K., Kagami, H., Sano, A., Matsubara, Y., Tagami, T., Naito, M. Anim. Genet. (2001) [Pubmed]
Localization of IGF1R and EDN genes to pig chromosomes 1 and 7 by in situ hybridization. Lahbib-Mansais, Y., Yerle, M., Gellin, J. Cytogenet. Cell Genet. (1995) [Pubmed]
Immunohistochemical detection of components of the insulin-like growth factor system during skeletal muscle growth in the pig. Götz, W., Dittjen, O., Wicke, M., Biereder, S., Krüger, U., von Lengerken, G. Anatomia, histologia, embryologia. (2001) [Pubmed]

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