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Gene Review

IGFBP3  -  insulin-like growth factor binding protein 3

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Disease relevance of IGFBP-3

  • IUGR was associated with elevated plasma IGFBP-2 and IGFBP-4 and reduced IGFBP-3 levels [1].
  • In contrast to findings in T47D breast cancer cells, treatment of PEMC cultures with IGFBP-3 did not result in increased levels of phosphosmad-2 [2].
  • After 7 days of treatment, plasma IGFBP-3 concentrations and the plasma glucose response to a meal were also greater in pGH-treated than control pigs. pGH treatment significantly increased body weight gain and food conversion efficiency and the protein synthesis rate in several visceral organs [3].

Psychiatry related information on IGFBP-3


High impact information on IGFBP-3

  • Forskolin induced IGFBP-3 reporter activity in transiently transfected granulosa cells [5].
  • We conclude that FSH stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK pathways [5].
  • IGFBP-1, -2, -4, and -5 were of intermediate effectiveness as inhibitors, 3- to 11-fold less active than IGFBP-3 [6].
  • One of these binding proteins, IGFBP-3, affects cell proliferation via both IGF-dependent and IGF-independent mechanisms and it has generally been shown to suppress proliferation of cultured cells; however, it also may stimulate proliferation depending upon the cell type and the assay conditions [7].
  • Treatment of porcine embryonic myogenic cell (PEMC) cultures with either TGF-beta(1) or GDF-8 suppressed proliferation and increased production of IGFBP-3 protein and mRNA (P < 0.005) [2].

Biological context of IGFBP-3


Anatomical context of IGFBP-3


Associations of IGFBP-3 with chemical compounds

  • The PEM isolated from sows fed L-carnitine had decreased IGF-II (P = 0.02), IGFBP-3 (P = 0.03), and myogenin (P = 0.04; 61, 59, and 67%, respectively) mRNA abundance compared with controls [15].
  • IGFBP-4 is an inhibitor of basal progesterone, oxytocin and IGFBP-3 release and a stimulator of IGF-I output by porcine ovarian cells [16].
  • It was observed that GH, IGF-I, estradiol, LH and oxytocin alter the progesterone, oxytocin, IGF-I and IGFBP-3 release by porcine ovarian granulosa cells [16].
  • Dot-blot analyses for IGF-I and IGFBP-3 mRNAs were performed on total RNA from small and large luteal cells; blots were counter-probed with 3-phosphoglyceraldehyde dehydrogenase (p-GAD) cDNA to assess RNA quantity and quality [17].
  • The present results suggested that IGFBP-4, as well as GH, IGF-I, estradiol, LH and oxytocin, is a potent regulator of porcine ovarian steroid (progesterone), nonapeptide hormone (oxytocin), growth factor (IGF-I) and growth factor-binding protein (IGFBP-3) release [16].

Regulatory relationships of IGFBP-3

  • The simultaneous decrease in IGFBP-3 mRNA and protein that accompanies IGF-I-induced myogenin expression suggests that differentiation of myogenic cells may be preceded or accompanied by decreased production of IGFBP-3 [8].

Other interactions of IGFBP-3

  • No treatment effect was found for muscle IGF-I (P = 0.36), IGF-II (P = 0.51), IGFBP-3 (P = 0.70), or IGFBP-5 (P = 0.51) mRNA abundance [15].
  • Higher magnification revealed that IGF1R, IGFBP-3 and probably IGF-I appeared in the tubular system [18].
  • An anti-IGFBP-3 antibody that neutralizes the biological activity of IGFBP-3 reduced the ability of either TGF-beta(1) or GDF-8 to suppress PEMC proliferation (P < 0.005) [2].
  • In conclusion, the data point to IGF-I, IGF-II, IGFBP-2, and IGFBP-3 as putative mediators of relaxin-induced uterine growth in the pig [19].
  • FFI IGFBP-3 was increased to a similar extent by GH (p < 0.005), but IGFBP-2 was not affected [20].

Analytical, diagnostic and therapeutic context of IGFBP-3


  1. Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in guinea pigs. Carter, A.M., Kingston, M.J., Han, K.K., Mazzuca, D.M., Nygard, K., Han, V.K. J. Endocrinol. (2005) [Pubmed]
  2. Role of insulin-like growth factor binding protein (IGFBP)-3 in TGF-beta- and GDF-8 (myostatin)-induced suppression of proliferation in porcine embryonic myogenic cell cultures. Kamanga-Sollo, E., Pampusch, M.S., White, M.E., Dayton, W.R. J. Cell. Physiol. (2003) [Pubmed]
  3. Exogenous growth hormone stimulates somatotropic axis function and growth in neonatal pigs. Wester, T.J., Davis, T.A., Fiorotto, M.L., Burrin, D.G. Am. J. Physiol. (1998) [Pubmed]
  4. Effect of recombinant porcine IGF-binding protein-3 on proliferation of embryonic porcine myogenic cell cultures in the presence and absence of IGF-I. Pampusch, M.S., Kamanga-Sollo, E., White, M.E., Hathaway, M.R., Dayton, W.R. J. Endocrinol. (2003) [Pubmed]
  5. Follicle-stimulating hormone induction of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and phosphatidylinositol-3 kinase pathways. Ongeri, E.M., Verderame, M.F., Hammond, J.M. Mol. Endocrinol. (2005) [Pubmed]
  6. Insulin-like growth factor binding proteins modulate Müller cell responses to insulin-like growth factors. King, J.L., Guidry, C. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  7. Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells. Xi, G., Kamanga-Sollo, E., Pampusch, M.S., White, M.E., Hathaway, M.R., Dayton, W.R. J. Cell. Physiol. (2004) [Pubmed]
  8. Effect of insulin-like growth factor (IGF)-I and Des (1-3) IGF-I on the level of IGF binding protein-3 and IGF binding protein-3 mRNA in cultured porcine embryonic muscle cells. Yang, F., Johnson, B.J., White, M.E., Hathaway, M.R., Dayton, W.R. J. Cell. Physiol. (1999) [Pubmed]
  9. Coordinate expression of the insulin-like growth factor system after microembolisation in porcine heart. Kluge, A., Zimmermann, R., Weihrauch, D., Mohri, M., Sack, S., Schaper, J., Schaper, W. Cardiovasc. Res. (1997) [Pubmed]
  10. Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in porcine serum during fetal and postnatal development. Lee, C.Y., Bazer, F.W., Etherton, T.D., Simmen, F.A. Endocrinology (1991) [Pubmed]
  11. Selective expression of insulin-like growth factor system components during porcine ovary follicular selection. Zhou, J., Adesanya, O.O., Vatzias, G., Hammond, J.M., Bondy, C.A. Endocrinology (1996) [Pubmed]
  12. Insulin-like growth factor-binding protein-2 and -3 are correlated with atresia and preovulatory maturation in the porcine ovary. Grimes, R.W., Guthrie, H.D., Hammond, J.M. Endocrinology (1994) [Pubmed]
  13. Depletion of insulin in streptozocin-induced-diabetic pigs alters estradiol, insulin-like growth factor (IGF)-I and IGF binding proteins in cultured ovarian follicles. Edwards, J.L., Hughey, T.C., Moore, A.B., Cox, N.M. Biol. Reprod. (1996) [Pubmed]
  14. The unique endometrial expression and genomic organization of the porcine IGFBP-2 gene. Song, S., Lee, C.Y., Green, M.L., Chung, C.S., Simmen, R.C., Simmen, F.A. Mol. Cell. Endocrinol. (1996) [Pubmed]
  15. Effects of L-carnitine on fetal growth and the IGF system in pigs. Waylan, A.T., Kayser, J.P., Gnad, D.P., Higgins, J.J., Starkey, J.D., Sissom, E.K., Woodworth, J.C., Johnson, B.J. J. Anim. Sci. (2005) [Pubmed]
  16. The transfection-induced overexpression of IGF-binding protein-4 affects the secretory activity of porcine ovarian granulosa cells and their response to hormones and IGF-I. Sirotkin, A.V., Makarevich, A.V., Corkins, M.R., Kotwica, J., Bulla, J. J. Mol. Endocrinol. (2001) [Pubmed]
  17. Expression of the messenger ribonucleic acids for insulin-like growth factor-I and insulin-like growth factor binding proteins in porcine corpora lutea. Gadsby, J.E., Lovdal, J.A., Samaras, S., Barber, J.S., Hammond, J.M. Biol. Reprod. (1996) [Pubmed]
  18. Immunohistochemical detection of components of the insulin-like growth factor system during skeletal muscle growth in the pig. Götz, W., Dittjen, O., Wicke, M., Biereder, S., Krüger, U., von Lengerken, G. Anatomia, histologia, embryologia. (2001) [Pubmed]
  19. Relaxin increases insulin-like growth factors (IGFs) and IGF-binding proteins of the pig uterus in vivo. Ohleth, K.M., Lenhart, J.A., Ryan, P.L., Radecki, S.V., Bagnell, C.A. Endocrinology (1997) [Pubmed]
  20. Effects of growth hormone and gonadotropin on the insulin-like growth factor system in the porcine ovary. Samaras, S.E., Hagen, D.R., Bryan, K.A., Mondschein, J.S., Canning, S.F., Hammond, J.M. Biol. Reprod. (1994) [Pubmed]
  21. Do GH, IGF-I and oxytocin interact by regulating the secretory activity of porcine ovarian cells? Sirotkin, A.V., Makarevich, A.V., Kwon, H.B., Kotwica, J., Bulla, J., Hetényi, L. J. Endocrinol. (2001) [Pubmed]
  22. Short-term infusion of LongR(3) insulin-like growth factor (IGF)-I decreases hepatic IGF-I mRNA but not IGF binding protein-3 mRNA expression in pigs. Dunaiski, V., Dunshea, F.R., Walton, P.E., Goddard, C. Gen. Comp. Endocrinol. (2002) [Pubmed]
  23. Regulation of insulin-like growth factor binding proteins in young growing animals by alteration of energy status. Dauncey, M.J., Rudd, B.T., White, D.A., Shakespear, R.A. Growth Regul. (1993) [Pubmed]
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