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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

qacC  -  multi-drug efflux pump

Staphylococcus aureus

 
 
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Disease relevance of qacC

 

High impact information on qacC

  • The current study evaluated whether (i) transporters encoded by the qacB and qacC multidrug resistance genes also confer tPMP-1r and (ii) tPMP-1r mediated by qacA is dependent on efflux pump activity [2].
 

Biological context of qacC

  • Of note, the qacA-bearing strain exhibited greater membrane fluidity than that of the parental, qacB-, or qacC-bearing strain [2].
  • Sequence analysis has revealed that pSK108 is a member of the pC194 family of rolling circle replicating plasmids and suggests that the DNA segment containing qacC, which is bounded by the replication nick site and the minus origin palA, represents a resistance gene cassette that has undergone horizontal genetic exchange [1].

References

  1. Multidrug resistance plasmid pSK108 from coagulase-negative staphylococci; relationships to Staphylococcus aureus qacC plasmids. Leelaporn, A., Firth, N., Paulsen, I.T., Hettiaratchi, A., Skurray, R.A. Plasmid (1995) [Pubmed]
  2. Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Bayer, A.S., Kupferwasser, L.I., Brown, M.H., Skurray, R.A., Grkovic, S., Jones, T., Mukhopadhay, K., Yeaman, M.R. Antimicrob. Agents Chemother. (2006) [Pubmed]
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