Gene Review:
qacA - efflux protein QacA
Staphylococcus aureus
- Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. Rouch, D.A., Cram, D.S., DiBerardino, D., Littlejohn, T.G., Skurray, R.A. Mol. Microbiol. (1990)
- Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug- resistant Staphylococcus haemolyticus strains of animal and human origins. Anthonisen, I.L., Sunde, M., Steinum, T.M., Sidhu, M.S., Sørum, H. Antimicrob. Agents Chemother. (2002)
- Frequency of disinfectant resistance genes and genetic linkage with beta-lactamase transposon Tn552 among clinical staphylococci. Sidhu, M.S., Heir, E., Leegaard, T., Wiger, K., Holck, A. Antimicrob. Agents Chemother. (2002)
- Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome. Noguchi, N., Nakaminami, H., Nishijima, S., Kurokawa, I., So, H., Sasatsu, M. J. Clin. Microbiol. (2006)
- Structural mechanisms of QacR induction and multidrug recognition. Schumacher, M.A., Miller, M.C., Grkovic, S., Brown, M.H., Skurray, R.A., Brennan, R.G. Science (2001)
- QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. Grkovic, S., Brown, M.H., Roberts, N.J., Paulsen, I.T., Skurray, R.A. J. Biol. Chem. (1998)
- Distribution of the antiseptic resistance genes qacA, qacB and qacC in 497 methicillin-resistant and -susceptible European isolates of Staphylococcus aureus. Mayer, S., Boos, M., Beyer, A., Fluit, A.C., Schmitz, F.J. J. Antimicrob. Chemother. (2001)
- Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus. Tennent, J.M., Lyon, B.R., Midgley, M., Jones, I.G., Purewal, A.S., Skurray, R.A. J. Gen. Microbiol. (1989)
- Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Bayer, A.S., Kupferwasser, L.I., Brown, M.H., Skurray, R.A., Grkovic, S., Jones, T., Mukhopadhay, K., Yeaman, M.R. Antimicrob. Agents Chemother. (2006)
- Genetic linkage between resistance to quaternary ammonium compounds and beta-lactam antibiotics in food-related Staphylococcus spp. Sidhu, M.S., Heir, E., Sørum, H., Holck, A. Microb. Drug Resist. (2001)
- Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus. Noguchi, N., Hase, M., Kitta, M., Sasatsu, M., Deguchi, K., Kono, M. FEMS Microbiol. Lett. (1999)
- Do biocides select for antibiotic resistance? Russell, A.D. J. Pharm. Pharmacol. (2000)
- Identification and characterization of quaternary ammonium compound resistant staphylococci from the food industry. Heir, E., Sundheim, G., Holck, A.L. Int. J. Food Microbiol. (1999)
- Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Paulsen, I.T., Brown, M.H., Littlejohn, T.G., Mitchell, B.A., Skurray, R.A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999. Noguchi, N., Suwa, J., Narui, K., Sasatsu, M., Ito, T., Hiramatsu, K., Song, J.H. J. Med. Microbiol. (2005)
- Multidrug resistance to antiseptics and disinfectants in coagulase-negative staphylococci. Leelaporn, A., Paulsen, I.T., Tennent, J.M., Littlejohn, T.G., Skurray, R.A. J. Med. Microbiol. (1994)