Disease relevance of Membrane Fluidity

• Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17 beta-estradiol [1].
• Influenza virus did not alter membrane fluidity as measured by electron spin resonance spectroscopy with the probe 5-doxyl stearate [2].
• Modulation by S-adenosyl-L-methionine of hepatic Na+,K+-ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis [3].
• Influence of membrane fluidity on the assembly of Staphylococcus aureus alpha-toxin, a channel-forming protein, in liposome membrane [4].
• Effect of glyburide in type II diabetes mellitus. Studies of monocyte membrane fluidity, lipid composition, and insulin binding [5].

Psychiatry related information on Membrane Fluidity

• OBJECTIVE: The primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheimer's disease and its relationship to the APOE epsilon4 genotype [6].
• Piracetam treatment improved active avoidance learning in the aged rats only and elevated membrane fluidity in all brain regions except the cerebellum in the aged animals [7].
• 3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease [8].

High impact information on Membrane Fluidity

• The OLE pathway of yeast regulates the level of the ER-bound enzyme Delta9-fatty acid desaturase OLE1, thereby controlling membrane fluidity [9].
• Surprisingly, the action of arachidonic acid is unaffected by cyclo-oxygenase or lipoxygenase inhibitors suggesting that it inhibits uptake directly, possibly by increasing membrane fluidity [10].
• Membrane fluidity of a fatty acid auxotroph grown with palmitic acid [11].
• Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity [12].
• Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity [13].

Chemical compound and disease context of Membrane Fluidity

• Membrane fluidity modulates cell function, and reduced membrane fluidity in cholesterol-enriched platelets is associated with platelet hypersensitivity to agonists, including thrombin [14].
• Cholesterol depletion caused substantial reduction in anisotropy of the VS virion membrane as measured by fluorescence depolarization of the lipophilic probe 1,6-diphenyl-1,3,5-hexatriene; residual adsorbed vesicles represent a significant factor in this apparent increase in virion membrane fluidity [15].
• CONCLUSIONS--The factors that most influence membrane fluidity in IDDM patients appear to be hyperglycemia and ketone bodies [16].
• Here, we modulated membrane fluidity of human neuroblastoma CHP100 cells by modulating their cholesterol content, and investigated the ability of gp120 to induce cell death in comparison with the untreated cells [17].
• A concept is introduced which proposes that infection of cells with the human immunodeficiency virus causes a rise in cellular oleic acid which leads to increased membrane fluidity [18].

Biological context of Membrane Fluidity

• Cell growth with trans fatty acids is affected by adenosine 3',5'-monophosphate and membrane fluidity [19].
• Inheritance pattern of platelet membrane fluidity in Alzheimer disease [20].
• P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential [21].
• Insulin-receptor development in normal and diabetic pregnancies. Role of membrane fluidity [22].
• Pentoxifylline, an agent that has previously been studied for its ability to prevent some effects of rhTNF alpha on PMNs, completely prevented the effect of rhTNF alpha on chemotaxis, the expression of the CD11b antigen, and membrane fluidity [23].

Anatomical context of Membrane Fluidity

• A higher membrane fluidity and lower cholesterol-to-phospholipid ratio were found in the jejunum [24].
• In vitro treatment of both mice and human CHS erythrocytes with 10 mM ascorbate returned their membrane fluidity to normal [25].
• Here, Irving Fritz and Edoardo Arrigoni-Martelli review the evidence that carnitine and its O-acyl derivatives also influence membrane fluidity, ion channel functions, smooth muscle contractility, membrane stability and cardiac functions [26].
• Low doses of n-butanol (0.25%) and n-pentanol (0.1%) were nontoxic to the leukocytes yet reduced their diphenylhexatriene-induced polarization, indicating increased membrane fluidity [27].
• The contributing factors include the intrinsic rate of proton leakage across the inner mitochondrial membrane (a correlate of oxidant formation), decreased membrane fluidity, and decreased levels and function of cardiolipin, which supports the function of many of the proteins of the inner mitochondrial membrane [28].

Associations of Membrane Fluidity with chemical compounds

• Recent technological advances enable simultaneous monitoring of specific cell functions and glycoprotein motility, making it possible to correlate membrane fluidity and active glycoprotein movements with cell function [29].
• The reduction in Na+-dependent D-glucose transport correlated with ischemic-induced changes in the BBM SPH/PC and cholesterol-to-phospholipid ratios and membrane fluidity [30].
• The acute addition of ethanol (up to 1 M) in vitro to the control BBMVs increased both membrane fluidity and calcium accumulation [31].
• Inclusion of lipid in the parenterally administered hyperalimentation solution normalized microsomal membrane fluidity and lipid profile to those of chow-fed animals but did not increase hepatic meperidine demethylation [32].
• Because changes in membrane fluidity and lipid composition are reported to influence activity of a number of liver enzymes, effects of parenteral and enteral nutrition on hepatic microsomal membrane fluidity and lipid composition were assessed and compared with hepatic mixed-function oxidase activity [32].

Gene context of Membrane Fluidity

• These results suggest that expression of P-gp per se has little effect on membrane fluidity or membrane potential, and it does not have H(+) pump activity [21].
• This suggests that Sln1p monitors changes in membrane fluidity caused by cold [33].
• The increase of homotypic aggregation was accompanied by up-regulation of intercellular adhesion molecule 1 but not lymphocyte function-associated antigen 1 expression on cells and by an elevation of membrane fluidity, both of which were up-regulated by anti-75- but not 55-kDa TNF-R antibody [34].
• Expression of alpha-fetoprotein and interleukin 2 receptors and impairment of membrane fluidity in peripheral blood mononuclear cells from AIDS and related syndromes [35].
• Results indicated the importance of membrane fluidity on the apparent tyrosine kinase activity of reconstituted EGFR [36].

Analytical, diagnostic and therapeutic context of Membrane Fluidity

• Using flow cytometry with the excimer-forming lipid technique with pyrenedecanoic acid, we measured membrane fluidity of polymorphonuclear leukocytes (PMNs) from 20 streptozocin (STZ)-induced diabetic rats [37].
• These studies demonstrate that a cholestrol-enriched, atherogenic diet causes profound and reversible changes in the lipid composition, membrane fluidity, and morphology of red cells in dogs [38].
• Uptake was determined by a rapid filtration method and membrane fluidity by measuring the steady-state fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene [39].
• The membrane fluidity measurements by 12-doxyl stearate indicate that there are two distinct modes of spin-label interaction in PHZ-treated cell membrane, the one corresponding to more immobilization gaining with the PHZ concentration, while MMH has only minor effects on fluidity [40].
• These results were confirmed using fluorescence anisotropy to evaluate the effect of Abeta on membrane fluidity and fluorimetry to confirm membrane integrity [41].

References