Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

nkx2-3-a - NK2 homeobox 3

Xenopus laevis

Synonyms: nkx-2.3, nkx-2.3a, nkx2.3, xnkx-2.3, xnkx2-3

Ma, C.M., Evans, S.M. et al., Cleaver, O.B. et al.

Ma,

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Disease relevance of XNkx-2.3

Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia [1].

High impact information on XNkx-2.3

As the helix-loop-helix factor Twist is thought to regulate tinman expression in Drosophila, we have compared the expression of XNkx-2.3 and Xtwist during embryonic development in Xenopus [2].
First, XNkx-2.3 was expressed in tadpole skin during metamorphosis (stages 55-59), but not in pre-metamorphic (stage 54) skin [3].
Using PCR cloning, the mRNA of XNkx-2.3 gene, a Xenopus tinman homologue, was identified in a cDNA library prepared from thyroid hormone (T(3))-treated tadpole skin [3].

Analytical, diagnostic and therapeutic context of XNkx-2.3

In situ hybridization indicated that XNkx-2.3 was expressed in the frog epidermis [3].
Quantitative RT-PCR and RNase Protection Assay confirmed the expression of XNkx-2.3 in adult frog skin and its amount was similar to the amount found in heart [3].

References

Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Cleaver, O.B., Patterson, K.D., Krieg, P.A. Development (1996) [Pubmed]
tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Evans, S.M., Yan, W., Murillo, M.P., Ponce, J., Papalopulu, N. Development (1995) [Pubmed]
Spatial and temporal expression patterns of Xenopus Nkx-2.3 gene in skin epidermis during metamorphosis. Ma, C.M. Gene Expr. Patterns (2004) [Pubmed]

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