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Gene Review:

cdc7 - cell division cycle 7

Xenopus laevis

Sato, N. et al., Pereverzeva, I. et al., Silva, T. et al., Costanzo, V. et al., Takahashi, T.S. et al., et al.

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High impact information on Cdc7

Cdc7, a protein kinase required for the initiation of eukaryotic DNA replication, is activated by a regulatory subunit, Dbf4 [1].
This is the biochemical demonstration of a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase [2].
Upon checkpoint activation, a prereplicative complex is assembled that contains ORC, Cdc6, Cdc7, and MCM proteins but lacks Cdc45 [3].
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7 [4].
Following exit from mitosis, the Mcm4 subunit of the cytosolic interphase complex undergoes dephosphorylation, and the Mcm2, Mcm3, or Mcm6 subunits are then actively phosphorylated by kinase(s) other than cyclin-dependent kinases (Cdks) or Cdc7 [5].

Biological context of Cdc7

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase [6].
Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest [7].
These data suggest that Cdc7/Drf1 but not Cdc7/Dbf4 complexes support the initiation of DNA replication in Xenopus egg extracts and during early embryonic development [8].

References

Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Takahashi, T.S., Walter, J.C. Genes Dev. (2005) [Pubmed]
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Costanzo, V., Shechter, D., Lupardus, P.J., Cimprich, K.A., Gottesman, M., Gautier, J. Mol. Cell (2003) [Pubmed]
Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Costanzo, V., Robertson, K., Ying, C.Y., Kim, E., Avvedimento, E., Gottesman, M., Grieco, D., Gautier, J. Mol. Cell (2000) [Pubmed]
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. Sato, N., Arai, K., Masai, H. EMBO J. (1997) [Pubmed]
Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex. Pereverzeva, I., Whitmire, E., Khan, B., Coué, M. Mol. Cell. Biol. (2000) [Pubmed]
DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase. Roberts, B.T., Ying, C.Y., Gautier, J., Maller, J.L. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. Yanow, S.K., Gold, D.A., Yoo, H.Y., Dunphy, W.G. J. Biol. Chem. (2003) [Pubmed]
Xenopus CDC7/DRF1 Complex Is Required for the Initiation of DNA Replication. Silva, T., Bradley, R.H., Gao, Y., Coue, M. J. Biol. Chem. (2006) [Pubmed]

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