Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

jag1 - jagged 1

Xenopus laevis

Synonyms: jagged1, serrate, serrate-1, x-serrate-1

Kiyota, T. et al., Kiyota, T. et al., Kiyota, T. et al.

Kiyota, Jono, Kuriyama, Hasegawa, Miyatani, Kinoshita,

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High impact information on X-Serrate-1

Moreover, we propose a bi-directional signaling pathway mediated by X-Serrate-1 in Notch signaling [1].
The animal cap assay revealed that X-Serrate-1 suppresses primary neurogenesis in neuralized animal cap, but X-Delta-1 does not [1].
Expression of X-Serrate-1 was observed ubiquitously from unfertilized egg to tadpole, but an upregulation occurred in the tailbud stage embryo [2].
Here we report gene expression patterns and functional characterization of a Xenopus Serrate homolog, X-Serrate-1 [2].
Overexpression of X-Delta-1 and X-Serrate-1 strongly induced the expression of Xenopus ESR-1 (XESR-1), a gene related to Drosophila Enhancer of split [3].

References

The intracellular domain of X-Serrate-1 is cleaved and suppresses primary neurogenesis in Xenopus laevis. Kiyota, T., Kinoshita, T. Mech. Dev. (2004) [Pubmed]
X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1. Kiyota, T., Jono, H., Kuriyama, S., Hasegawa, K., Miyatani, S., Kinoshita, T. Dev. Genes Evol. (2001) [Pubmed]
Cysteine-rich region of X-Serrate-1 is required for activation of Notch signaling in Xenopus primary neurogenesis. Kiyota, T., Kinoshita, T. Int. J. Dev. Biol. (2002) [Pubmed]

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