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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ovum

  • The Ova gene was expressed in Escherichia coli with high yield using the T7 phage promoter; the amount of the recombinant Ova (re-Ova) was 29.4% of cellular proteins [1].
  • Tetanus toxoid was found to be the most stable in the presence of anhydride monomers, while Ova was most stable in the presence of sebacic acid, and lysozyme was stable when incubated with all of the monomers studied [2].
  • Tc maintained bone formation indices almost at Ova level, and only decreased mineral apposition rate (MAR) in Tc1 group, and declined bone resorption perimeter [3].

High impact information on Ovum

  • Nucleotide analyses of 3H-methyl methionine-labeled RNA in two-cell embryos and in unfertilized eggs show that fertilization activates the cap methylation of about 10(7) RNA molecules [4].
  • Finally, the direct microinjection of constitutively active CaM KII into unfertilized eggs inactivates Cdc2 kinase and CSF, even in the absence of a Ca2+ transient [5].
  • Thus, Rsk appears to be the mediator of MAPK-dependent CSF arrest in vertebrate unfertilized eggs [6].
  • Xlim-1 mRNA is found at low abundance in the unfertilized egg, has a major expression phase at the gastrula stage, decreases, and rises again during the tadpole stage [7].
  • Using these libraries, we now report the first stages at which the cytokines interleukin (IL)-6, IL-1 beta, and interferon (IFN)-gamma are transcribed in the developing embryo and the presence of IL-7 transcripts in the unfertilized egg [8].

Chemical compound and disease context of Ovum

  • This study focuses on the effects of polymer degradation products on the primary, secondary, and tertiary structure of tetanus toxoid, ovalbumin (Ova), and lysozyme after incubation for 0 or 20 days in the presence of ester (lactic acid and glycolic acid) and anhydride (sebacic acid and 1,6-bis(p-carboxyphenoxy)hexane) monomers [2].

Biological context of Ovum


Anatomical context of Ovum


Associations of Ovum with chemical compounds

  • Electron microscopic localization on unfertilized eggs using peroxidase-labeled secondary antibody demonstrated the presence of the CSL protein within the luminal compartment of ER-like tubules [19].
  • Additional experiments with the phorbol ester, phorbol myristate acetate, demonstrate that activating protein synthesis alone in unfertilized eggs does not result in stimulation of p34cdc2 tyrosine kinase activity [20].
  • Isolation and structures of glycoprotein-derived free sialooligosaccharides from the unfertilized eggs of Tribolodon hakonensis, a dace. Intracellular accumulation of a novel class of biantennary disialooligosaccharides [21].
  • Structural studies of fertilization-associated carbohydrate-rich glycoproteins (hyosophorin) isolated from the fertilized and unfertilized eggs of flounder, Paralichthys olivaceus. Presence of a novel penta-antennary N-linked glycan chain in the tandem repeating glycopeptide unit of hyosophorin [22].
  • Analysis of immunoblots prepared from fertilized and unfertilized eggs revealed that fertilization results in a major increase in the phosphotyrosine content of a 350-kDa egg protein [23].

Gene context of Ovum


Analytical, diagnostic and therapeutic context of Ovum


  1. Production of chicken ovalbumin in Escherichia coli. Takahashi, N., Orita, T., Hirose, M. Gene (1995) [Pubmed]
  2. Protein stability in the presence of polymer degradation products: consequences for controlled release formulations. Determan, A.S., Wilson, J.H., Kipper, M.J., Wannemuehler, M.J., Narasimhan, B. Biomaterials (2006) [Pubmed]
  3. Effects of low doses of hydrochloride tetracycline on bone metabolism and uterus in ovariectomized rats. Li, Q.N., Hu, B., Huang, L.F., Chen, Y., Weng, L.L., Zheng, H., Chen, H.Q. Acta Pharmacol. Sin. (2003) [Pubmed]
  4. The role of cap methylation in the translational activation of stored maternal histone mRNA in sea urchin embryos. Caldwell, D.C., Emerson, C.P. Cell (1985) [Pubmed]
  5. Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Lorca, T., Cruzalegui, F.H., Fesquet, D., Cavadore, J.C., Méry, J., Means, A., Dorée, M. Nature (1993) [Pubmed]
  6. Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk. Gross, S.D., Schwab, M.S., Lewellyn, A.L., Maller, J.L. Science (1999) [Pubmed]
  7. The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Taira, M., Jamrich, M., Good, P.J., Dawid, I.B. Genes Dev. (1992) [Pubmed]
  8. Gene expression during preimplantation mouse development. Rothstein, J.L., Johnson, D., DeLoia, J.A., Skowronski, J., Solter, D., Knowles, B. Genes Dev. (1992) [Pubmed]
  9. Mos and the cell cycle: the molecular basis of the transformed phenotype. Yew, N., Strobel, M., Vande Woude, G.F. Curr. Opin. Genet. Dev. (1993) [Pubmed]
  10. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. Axton, J.M., Shamanski, F.L., Young, L.M., Henderson, D.S., Boyd, J.B., Orr-Weaver, T.L. EMBO J. (1994) [Pubmed]
  11. Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction. Schuel, H., Goldstein, E., Mechoulam, R., Zimmerman, A.M., Zimmerman, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. Ser-3 is important for regulating Mos interaction with and stimulation of mitogen-activated protein kinase kinase. Chen, M., Cooper, J.A. Mol. Cell. Biol. (1995) [Pubmed]
  13. Dominant-negative mutant dynein allows spontaneous centrosome assembly, uncouples chromosome and centrosome cycles. Belecz, I., Gonzalez, C., Puro, J., Szabad, J. Curr. Biol. (2001) [Pubmed]
  14. Purification of a novel, nucleoplasmin-like protein from somatic nuclei. Cotten, M., Chalkley, R. EMBO J. (1987) [Pubmed]
  15. Accumulation of proto-oncogene c-erb-A related transcripts during Xenopus development: association with early acquisition of response to thyroid hormone and estrogen. Baker, B.S., Tata, J.R. EMBO J. (1990) [Pubmed]
  16. Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis. Asashima, M., Nakano, H., Uchiyama, H., Sugino, H., Nakamura, T., Eto, Y., Ejima, D., Nishimatsu, S., Ueno, N., Kinoshita, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  17. Maternal mRNAs of PEM and macho 1, the ascidian muscle determinant, associate and move with a rough endoplasmic reticulum network in the egg cortex. Sardet, C., Nishida, H., Prodon, F., Sawada, K. Development (2003) [Pubmed]
  18. Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Duhl, D.M., Stevens, M.E., Vrieling, H., Saxon, P.J., Miller, M.W., Epstein, C.J., Barsh, G.S. Development (1994) [Pubmed]
  19. A calsequestrin-like protein in the endoplasmic reticulum of the sea urchin: localization and dynamics in the egg and first cell cycle embryo. Henson, J.H., Begg, D.A., Beaulieu, S.M., Fishkind, D.J., Bonder, E.M., Terasaki, M., Lebeche, D., Kaminer, B. J. Cell Biol. (1989) [Pubmed]
  20. A cyclin-abundance cycle-independent p34cdc2 tyrosine phosphorylation cycle in early sea urchin embryos. Edgecombe, M., Patel, R., Whitaker, M. EMBO J. (1991) [Pubmed]
  21. Isolation and structures of glycoprotein-derived free sialooligosaccharides from the unfertilized eggs of Tribolodon hakonensis, a dace. Intracellular accumulation of a novel class of biantennary disialooligosaccharides. Inoue, S., Iwasaki, M., Ishii, K., Kitajima, K., Inoue, Y. J. Biol. Chem. (1989) [Pubmed]
  22. Structural studies of fertilization-associated carbohydrate-rich glycoproteins (hyosophorin) isolated from the fertilized and unfertilized eggs of flounder, Paralichthys olivaceus. Presence of a novel penta-antennary N-linked glycan chain in the tandem repeating glycopeptide unit of hyosophorin. Seko, A., Kitajima, K., Iwasaki, M., Inoue, S., Inoue, Y. J. Biol. Chem. (1989) [Pubmed]
  23. Protein tyrosine phosphorylation in response to fertilization. Peaucellier, G., Veno, P.A., Kinsey, W.H. J. Biol. Chem. (1988) [Pubmed]
  24. Genetic and molecular analysis of spe-27, a gene required for spermiogenesis in Caenorhabditis elegans hermaphrodites. Minniti, A.N., Sadler, C., Ward, S. Genetics (1996) [Pubmed]
  25. Expression of Fgfr2 in the early mouse embryo indicates its involvement in preimplantation development. Haffner-Krausz, R., Gorivodsky, M., Chen, Y., Lonai, P. Mech. Dev. (1999) [Pubmed]
  26. TDPOZ, a family of bipartite animal and plant proteins that contain the TRAF (TD) and POZ/BTB domains. Huang, C.J., Chen, C.Y., Chen, H.H., Tsai, S.F., Choo, K.B. Gene (2004) [Pubmed]
  27. Obox, a family of homeobox genes preferentially expressed in germ cells. Rajkovic, A., Yan, C., Yan, W., Klysik, M., Matzuk, M.M. Genomics (2002) [Pubmed]
  28. Nutritional and developmental regulation of insulin-like growth factors in fish. Duan, C. J. Nutr. (1998) [Pubmed]
  29. Embryonic-stage-dependent changes in the level of eIF4E-binding proteins during early development of sea urchin embryos. Salaün, P., Boulben, S., Mulner-Lorillon, O., Bellé, R., Sonenberg, N., Morales, J., Cormier, P. J. Cell. Sci. (2005) [Pubmed]
  30. Localization and developmental fate of ovoperoxidase and proteoliaisin, two proteins involved in fertilization envelope assembly. Somers, C.E., Battaglia, D.E., Shapiro, B.M. Dev. Biol. (1989) [Pubmed]
  31. Comparison of properties of calcium channels between the differentiated 1-cell embryo and the egg cell of ascidians. Hirano, T., Takahashi, K. J. Physiol. (Lond.) (1984) [Pubmed]
  32. Dynamics and unexpected localization of the plakin binding protein, kazrin, in mouse eggs and early embryos. Gallicano, G.I., Foshay, K., Pengetnze, Y., Zhou, X. Dev. Dyn. (2005) [Pubmed]
  33. Expression pattern of HSP25 in mouse preimplantation embryo: heat shock responses during oocyte maturation. Kim, M., Geum, D., Khang, I., Park, Y.M., Kang, B.M., Lee, K.A., Kim, K. Mol. Reprod. Dev. (2002) [Pubmed]
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