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Gene Review:

aceA - isocitrate lyase

Escherichia coli UTI89

Höner Zu Bentrup, K. et al., Gould, T.A. et al., Cánovas, M. et al.

Höner Zu Bentrup, Miczak, Swenson, Russell,

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Disease relevance of aceA

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis [1].

High impact information on aceA

The role of isocitrate lyase (ICL) in the glyoxylate cycle and its necessity for persistence and virulence of Mycobacterium tuberculosis has been well described [1].
Only marginal similarity was observed between this open reading frame (ORF) (termed icl) and a second distinct ORF (named aceA) which exhibits a low similarity to other isocitrate lyases [2].
Moreover, the main metabolic pathways and carbon flow operating during cell biotransformation was that controlled by the ICDH/ICL ratio, which decreased from 8.0 to 2.5, and the phosphotransferase/ACS ratio, which increased from 2.1 to 5.2, after a NaCl pulse fivefold the steady-state level [3].

References

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Gould, T.A., van de Langemheen, H., Muñoz-Elías, E.J., McKinney, J.D., Sacchettini, J.C. Mol. Microbiol. (2006) [Pubmed]
Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. Höner Zu Bentrup, K., Miczak, A., Swenson, D.L., Russell, D.G. J. Bacteriol. (1999) [Pubmed]
Salt stress effects on the central and carnitine metabolisms of Escherichia coli. Cánovas, M., Bernal, V., Sevilla, A., Iborra, J.L. Biotechnol. Bioeng. (2007) [Pubmed]

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