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Gene Review: 

dlx5  -  distal-less homeobox 5

Xenopus laevis

Synonyms: X-dll3, dll3
 
 
 
 
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High impact information on Dlx5

  • Among this family, Dlx3 and Dlx5 share extensive sequence homology and have similar, but distinctive, expression patterns, suggesting that these two factors may have substantially redundant developmental functions [1].
  • Here we show that at the earliest phases of embryogenesis in Xenopus, there are significant differences between Dlx3 and Dlx5 expression and that this correlates with different functions in the restriction of neural crest and neural plate boundaries, respectively [1].
  • This correlates with the different expression domain boundaries in vivo for Dlx3 compared to Dlx5 and 6, suggesting that BMP signal attenuation could be the primary factor in determining these different patterns in the gastrula ectoderm [2].

References

  1. Distinct roles for Distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus. Luo, T., Matsuo-Takasaki, M., Sargent, T.D. Mol. Reprod. Dev. (2001) [Pubmed]
  2. Differential regulation of Dlx gene expression by a BMP morphogenetic gradient. Luo, T., Matsuo-Takasaki, M., Lim, J.H., Sargent, T.D. Int. J. Dev. Biol. (2001) [Pubmed]
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