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Gene Review

RGS7BP  -  regulator of G-protein signaling 7 binding...

Homo sapiens

Synonyms: R7 family-binding protein, R7BP, Regulator of G-protein signaling 7-binding protein
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High impact information on RGS7BP

  • Here, we identify R7BP, a novel neuronally expressed protein that binds R7-Gbeta5 complexes and shuttles them between the plasma membrane and nucleus [1].
  • R7BP is palmitoylated near its COOH terminus, which targets the protein to the plasma membrane [1].
  • Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family [1].
  • Here we have investigated mechanisms whereby R7BP controls the function of the R7 family [2].
  • These results suggest a novel mechanism whereby palmitoyltransferases and nuclear import receptors both utilize the C-terminal domain of R7BP to determine the trafficking fate of R7.Gbeta5.R7BP heterotrimers [2].

Anatomical context of RGS7BP


Associations of RGS7BP with chemical compounds


  1. Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. Drenan, R.M., Doupnik, C.A., Boyle, M.P., Muglia, L.J., Huettner, J.E., Linder, M.E., Blumer, K.J. J. Cell Biol. (2005) [Pubmed]
  2. R7BP Augments the Function of RGS7{middle dot}Gbeta5 Complexes by a Plasma Membrane-targeting Mechanism. Drenan, R.M., Doupnik, C.A., Jayaraman, M., Buchwalter, A.L., Kaltenbronn, K.M., Huettner, J.E., Linder, M.E., Blumer, K.J. J. Biol. Chem. (2006) [Pubmed]
  3. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. Martemyanov, K.A., Yoo, P.J., Skiba, N.P., Arshavsky, V.Y. J. Biol. Chem. (2005) [Pubmed]
  4. R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Hepler, J.R. Sci. STKE (2005) [Pubmed]
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