High impact information on RGS7BP

• Here, we identify R7BP, a novel neuronally expressed protein that binds R7-Gbeta5 complexes and shuttles them between the plasma membrane and nucleus [1].
• R7BP is palmitoylated near its COOH terminus, which targets the protein to the plasma membrane [1].
• Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family [1].
• Here we have investigated mechanisms whereby R7BP controls the function of the R7 family [2].
• These results suggest a novel mechanism whereby palmitoyltransferases and nuclear import receptors both utilize the C-terminal domain of R7BP to determine the trafficking fate of R7.Gbeta5.R7BP heterotrimers [2].

Anatomical context of RGS7BP

• R7BP is expressed throughout the entire central nervous system but not in any of the tested non-neuronal tissues [3].
• The closest homolog of R7BP is R9AP which was previously found to interact with RGS9 in photoreceptors [3].

Associations of RGS7BP with chemical compounds

• R7BP binds directly to R7-Gbeta(5) and the protein complex is tethered to the plasma membrane by addition of a lipid, palmitate, on R7BP [4].

References