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Gene Review

Rgs9bp  -  regulator of G-protein signalling 9...

Mus musculus

Synonyms: R9AP, R9ap, RGS9-anchoring protein, Regulator of G-protein signaling 9-binding protein, Rgs9-1bp
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Disease relevance of Rgs9bp


High impact information on Rgs9bp


Biological context of Rgs9bp

  • Here we report the cloning of chicken R9AP from an inner ear cDNA library and the isolation of a murine R9AP cDNA from a retinal library [1].
  • The expression of R9AP beyond photoreceptors led us to examine potential alternative roles for R9AP besides anchoring RGS9-1 and we found sequence homology and structural similarity of the protein with members of the SNARE protein family [1].
  • Phosphorylation of RGS9-1 by PKC had little effect on its activity in solution but significantly decreased its affinity for its membrane anchor protein and GAP enhancer, RGS9-1 anchor protein (R9AP) [5].

Other interactions of Rgs9bp

  • This effect was a consequence of the complete absence of any detectable RGS9 from the retinas of R9AP knockout mice [4].

Analytical, diagnostic and therapeutic context of Rgs9bp

  • Interestingly, sequence analysis of R9AP reveals the presence of a conserved R-SNARE (for soluble N-ethylmaleimide-sensitive factor attachment protein receptor) motif and a predicted overall structural homology with SNARE proteins involved in vesicular trafficking and fusion [6].


  1. Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system. Keresztes, G., Mutai, H., Hibino, H., Hudspeth, A.J., Heller, S. Mol. Cell. Neurosci. (2003) [Pubmed]
  2. R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. Hu, G., Wensel, T.G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. Martemyanov, K.A., Yoo, P.J., Skiba, N.P., Arshavsky, V.Y. J. Biol. Chem. (2005) [Pubmed]
  4. Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. Keresztes, G., Martemyanov, K.A., Krispel, C.M., Mutai, H., Yoo, P.J., Maison, S.F., Burns, M.E., Arshavsky, V.Y., Heller, S. J. Biol. Chem. (2004) [Pubmed]
  5. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. Sokal, I., Hu, G., Liang, Y., Mao, M., Wensel, T.G., Palczewski, K. J. Biol. Chem. (2003) [Pubmed]
  6. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. Martemyanov, K.A., Lishko, P.V., Calero, N., Keresztes, G., Sokolov, M., Strissel, K.J., Leskov, I.B., Hopp, J.A., Kolesnikov, A.V., Chen, C.K., Lem, J., Heller, S., Burns, M.E., Arshavsky, V.Y. J. Neurosci. (2003) [Pubmed]
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