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Gene Review

Toll-9  -  CG5528 gene product from transcript CG5528-RA

Drosophila melanogaster

Synonyms: CG5528, CT17508, Dm Toll-9, Dmel\CG5528, TOLL 9, ...
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High impact information on Toll-9

  • Toll-9 activates strongly the expression of drosomycin, and utilizes similar signaling components to Toll-1 in activating the antifungal gene [1].
  • We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1 [1].
  • The predicted protein sequence of Toll-9 contains a tyrosine residue in place of a conserved cysteine, and this residue switch is critical for the high activity of Toll-9 [1].
  • In this paper we report the cloning and characterization of four TLR gene from malaria vector mosquito Anopheles gambiae, AgToll, AgToll6, AgTrex, and AgToll9, orthologues of DmToll, DmToll6, DmTollo (Toll8) and DmToll9 (CG5528) in Drosophila melanogaster [2].
  • Here we describe the embryonic expression patterns of the seven Toll-like genes Toll-3 through Toll-9 [3].

Other interactions of Toll-9

  • The Toll-9 gene is expressed in adult and larval stages prior to microbial challenge, and the expression correlates with the high constitutive level of drosomycin mRNA in the animals [1].


  1. The Drosophila Toll-9 activates a constitutive antimicrobial defense. Ooi, J.Y., Yagi, Y., Hu, X., Ip, Y.T. EMBO Rep. (2002) [Pubmed]
  2. Characterization of four Toll related genes during development and immune responses in Anopheles gambiae. Luna, C., Wang, X., Huang, Y., Zhang, J., Zheng, L. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  3. Tissue and stage-specific expression of the Tolls in Drosophila embryos. Kambris, Z., Hoffmann, J.A., Imler, J.L., Capovilla, M. Gene Expr. Patterns (2002) [Pubmed]
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