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Gene Review

Tollo  -  CG6890 gene product from transcript CG6890-RA

Drosophila melanogaster

Synonyms: CG6890, CT21344, Dmel\CG6890, TOLL 8, Tl-8, ...
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High impact information on Tollo

  • Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells [1].
  • Re-introduction of Tollo/Toll-8 into null embryos rescues neural-specific glycan expression [1].
  • In wild-type embryos, Tollo/Toll-8 is expressed by ectodermal cells that surround differentiating neurons and precedes HRP-epitope appearance [1].
  • Our data suggest that Tollo function might be redundant but is sufficient to antagonize Dpp signaling and induce sorting of Tollo expressing cells from the wing cells to develop proximal cell fate. genesis 44:541-549, 2006 [2].
  • In this paper we report the cloning and characterization of four TLR gene from malaria vector mosquito Anopheles gambiae, AgToll, AgToll6, AgTrex, and AgToll9, orthologues of DmToll, DmToll6, DmTollo (Toll8) and DmToll9 (CG5528) in Drosophila melanogaster [3].

Biological context of Tollo


Associations of Tollo with chemical compounds


Other interactions of Tollo

  • The extracellular domain of Tollo containing the Leucine-Rich Repeats (LRR) is required for the inhibition of Dpp signaling in the wing [2].


  1. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Seppo, A., Matani, P., Sharrow, M., Tiemeyer, M. Development (2003) [Pubmed]
  2. Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing. Kim, S., Chung, S., Yoon, J., Choi, K.W., Yim, J. Genesis (2006) [Pubmed]
  3. Characterization of four Toll related genes during development and immune responses in Anopheles gambiae. Luna, C., Wang, X., Huang, Y., Zhang, J., Zheng, L. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  4. Dynamic Developmental Elaboration of N-Linked Glycan Complexity in the Drosophila melanogaster Embryo. Aoki, K., Perlman, M., Lim, J.M., Cantu, R., Wells, L., Tiemeyer, M. J. Biol. Chem. (2007) [Pubmed]
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