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RhoBTB  -  Rho-related BTB domain containing

Drosophila melanogaster

Synonyms: 28574635, CG5701, Dmel\CG5701, RhoGTPase, RhoX
 
 
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High impact information on RhoBTB

  • Taking advantage of a new probe that allows the visualisation of small RhoGTPase activity in Drosophila, we present evidence that Rho1 is apically activated and essential for epithelial cell invagination, a common morphogenetic movement during embryogenesis [1].
  • Thus, Cv-c function is required in tissues actively undergoing morphogenesis, and we propose that its role is to regulate RhoGTPase activity to promote the coordinated organisation of the actin cytoskeleton, possibly by stabilising plasma membrane/actin cytoskeleton interactions [2].
  • Members of the RhoBTB subfamily of Rho GTPases are present in vertebrates, Drosophila and Dictyostelium [3].
  • We have also identified homologues for RacA in DROSOPHILA: and mammals, thus defining a new subfamily of Rho proteins, RhoBTB [4].

References

  1. Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Sim??es, S., Denholm, B., Azevedo, D., Sotillos, S., Martin, P., Skaer, H., Hombr??a, J.C., Jacinto, A. Development (2006) [Pubmed]
  2. crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. Denholm, B., Brown, S., Ray, R.P., Ruiz-Gómez, M., Skaer, H., Hombría, J.C. Development (2005) [Pubmed]
  3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos, S., Khademi, F., Somesh, B.P., Rivero, F. Gene (2002) [Pubmed]
  4. The Dictyostelium discoideum family of Rho-related proteins. Rivero, F., Dislich, H., Glöckner, G., Noegel, A.A. Nucleic Acids Res. (2001) [Pubmed]
 
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