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Gene Review

CD8A  -  CD8a molecule

Canis lupus familiaris

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Disease relevance of CD8A

  • The numbers of all cellular subpopulations in the dermis were significantly different between the groups, being highest in group A and lowest in group D. In sebaceous adenitis sites, CD4+ outnumbered CD8+ cells in contrast to the neighbouring dermis and the epidermis [1].

High impact information on CD8A

  • In the dermis, CD3+ cells in group A animals were mainly represented by the CD8+ [1].
  • In the epidermis, the low number of T-cells and their subsets did not differ significantly between groups A and B, but CD8+ outnumbered CD4+ lymphocytes in both groups [1].


  1. Cellular immunophenotyping of exfoliative dermatitis in canine leishmaniosis (Leishmania infantum). Papadogiannakis, E.I., Koutinas, A.F., Saridomichelakis, M.N., Vlemmas, J., Lekkas, S., Karameris, A., Fytianou, A. Vet. Immunol. Immunopathol. (2005) [Pubmed]
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