Disease relevance of Lymphadenitis

• Cells positive for IL-1 were detected in 16 of 21 cases of Hodgkin's disease, in 4 of 4 cases of T-NHL, and in 5 cases of diffuse or mixed lymphadenitis [1].
• Because of morphologic similarities between lupus lymphadenitis and Kikuchi's lymphadenitis, however, serologic studies are warranted to exclude systemic lupus erythematosus [2].
• Thereafter, unexpected cervical lymphadenitis from a Mycobacterium tuberculosis (TB) infection with high extra-renal production of calcitriol was found [3].
• We investigated serum levels of interferon alpha, interferon gamma, tumour necrosis factor alpha, interleukin-2 (IL-2) and interleukin-6 (IL-6) in patients with necrotizing lymphadenitis (Kikuchi's disease) (NL) [4].
• Corynebacterium pseudotuberculosis produces a sphingomyelin-specific phospholipase D exotoxin that is a major determinant in the pathogenesis of caseous lymphadenitis [5].

High impact information on Lymphadenitis

• INTERPRETATION: The initiation of indinavir therapy in patients with CD4 counts of less than 50 cells/mL and subclinical MAC infection may be associated with a severe illness, consisting of fever (> 39 degrees C), leucocytosis, and lymphadenitis (cervical, thoracic, or abdominal) [6].
• Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children [7].
• Patients with regional adenitis and good clinical outcomes had abundant OPN in infected lymph nodes [8].
• Immunoreactivity for IL-1 beta or TNF alpha was frequently observed in sections of granulomatous lymphadenitis (N = 11) [9].
• We offer the hypothesis that subacute necrotizing lymphadenitis with still unknown etiology may reflect a self-limited SLE-like autoimmune condition induced by virus-infected transformed lymphocytes [10].

Chemical compound and disease context of Lymphadenitis

• Lymphadenitis associated with the administration of clindamycin [11].
• Failure of treatment of tuberculous adenitis due to an unexpected drug interaction with rifabutin and efavirenz [12].
• Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis [13].
• Tuberculous iliac lymphadenitis: a rare complication of intravesical bacillus Calmette-Guerin and cause of tumor over staging [14].
• Clinical response to itraconazole therapy was obtained in 6 months; to our knowledge, this is the first report of lymphadenitis caused by S. apiospermum in humans [15].

Biological context of Lymphadenitis

• Infrequent detection of Toxoplasma gondii genome in toxoplasmic lymphadenitis: a polymerase chain reaction study [16].
• Apoptosis of histiocytes is a characteristic feature of necrotizing lymphadenitis (HNL) [17].
• Twenty-five isolates of Corynebacterium pseudotuberculosis from lesions of caseous lymphadenitis in goats were examined for cell wall lipid content, exotoxin production, and virulence in mice [18].

Anatomical context of Lymphadenitis

• In T cells from reactive lymph node biopsy specimens, CD25 was highly expressed only in dermatopathic lymphadenitis associated with transient skin rashes [19].
• Frozen lymph node biopsy specimens from 38 patients with B cell tumors, including 5 with childhood non-T-ALL and 3 with reactive lymphadenitis, were investigated using a direct immunohistochemical method to detect alpha-, beta- and gamma-enolases. alpha-Enolase-positive cells were not observed in reactive lymphadenitis [20].
• Calcium oxalate crystal deposition in epithelioid histiocytes of granulomatous lymphadenitis: analysis by light and electronmicroscopy [21].
• The ratio of RCAS1+ cells to CD68+ cells (monocytes/macrophages) was significantly higher in the patients with HNL than in the patients with reactive lymphadenitis (P = .0002; paired t test) [22].
• Submandibular glands with obstructive adenitis exhibited reduced CA-I activity in atrophic acinar cells, but not in ductal elements in the early and intermediate stages of the disorder [23].

Gene context of Lymphadenitis

• IL-4 production was not increased in the carriers except for one with a past history of toxoplasma lymphadenitis [24].
• T-bet expression in Kikuchi lymphadenitis underscores the hypothesis that it is caused by an intracellular microorganism [25].
• Expression of RCAS1 was analyzed by immunohistochemical staining in 9 cases of HNL and in 9 cases of reactive lymphadenitis used as a control [22].
• The remaining four child cases, as well as all adult cases with detectable IS6110, showed no motility shift in pncA PCR-SSCP and had the same one-band pattern as M. tuberculosis in oxyR PCR-RFLP, suggesting TB lymphadenitis [26].
• The following are 2 case reports of unsuspected MRSA infections: the first is an infant with cervical adenitis and the second is a child with a deep infection of the toe [27].

Analytical, diagnostic and therapeutic context of Lymphadenitis

• According, we performed immunohistochemical detection of CSF-1-positive cells on frozen sections of reactive lymphadenitis (three cases) and Hodgkin's disease (13 cases) lymph node biopsies, using as antibody a highly specific polyclonal rabbit antiserum prepared in our laboratory [28].
• Tissues from 10 patients with localized leishmania lymphadenitis were stained by immunoperoxidase technique for leishmanian antigens, immunoglobulins (Ig), complement, components, alpha 1-antitrypsin, and fibrin and by routine and chloroacetate esterase techniques [29].
• This is a case report of BCG dissemination with ulceration, skin necrosis, lymphadenitis, and abscess formation following the first intralesional injection of a minimal dose of BCG in a PPD-negative patient [30].
• The purpose of this communication is to re-emphasize the possibility of infection by group III Mycobacterium complex in the differential diagnosis of children with cervical lymphadenitis and to describe the important use of Auramine-O fluorescent stain in the early detection of this disease [31].
• A case of BCG lymphadenitis in a vertically infected HIV-positive boy 9.5 years after vaccination is presented [32].

References