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Disease relevance of Lymphadenitis


High impact information on Lymphadenitis

  • INTERPRETATION: The initiation of indinavir therapy in patients with CD4 counts of less than 50 cells/mL and subclinical MAC infection may be associated with a severe illness, consisting of fever (> 39 degrees C), leucocytosis, and lymphadenitis (cervical, thoracic, or abdominal) [6].
  • Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children [7].
  • Patients with regional adenitis and good clinical outcomes had abundant OPN in infected lymph nodes [8].
  • Immunoreactivity for IL-1 beta or TNF alpha was frequently observed in sections of granulomatous lymphadenitis (N = 11) [9].
  • We offer the hypothesis that subacute necrotizing lymphadenitis with still unknown etiology may reflect a self-limited SLE-like autoimmune condition induced by virus-infected transformed lymphocytes [10].

Chemical compound and disease context of Lymphadenitis


Biological context of Lymphadenitis


Anatomical context of Lymphadenitis


Gene context of Lymphadenitis

  • IL-4 production was not increased in the carriers except for one with a past history of toxoplasma lymphadenitis [24].
  • T-bet expression in Kikuchi lymphadenitis underscores the hypothesis that it is caused by an intracellular microorganism [25].
  • Expression of RCAS1 was analyzed by immunohistochemical staining in 9 cases of HNL and in 9 cases of reactive lymphadenitis used as a control [22].
  • The remaining four child cases, as well as all adult cases with detectable IS6110, showed no motility shift in pncA PCR-SSCP and had the same one-band pattern as M. tuberculosis in oxyR PCR-RFLP, suggesting TB lymphadenitis [26].
  • The following are 2 case reports of unsuspected MRSA infections: the first is an infant with cervical adenitis and the second is a child with a deep infection of the toe [27].

Analytical, diagnostic and therapeutic context of Lymphadenitis


  1. Cytokine production (IL-1 alpha, IL-1 beta, and TNF alpha) and endothelial cell activation (ELAM-1 and HLA-DR) in reactive lymphadenitis, Hodgkin's disease, and in non-Hodgkin's lymphomas. An immunocytochemical study. Ruco, L.P., Pomponi, D., Pigott, R., Stoppacciaro, A., Monardo, F., Uccini, S., Boraschi, D., Tagliabue, A., Santoni, A., Dejana, E. Am. J. Pathol. (1990) [Pubmed]
  2. Fine-needle aspiration cytologic diagnosis of Kikuchi's lymphadenitis. A report of 27 cases. Tsang, W.Y., Chan, J.K. Am. J. Clin. Pathol. (1994) [Pubmed]
  3. Diffuse calcinosis and intradermal tophi in a uremic pateint: effect of low-calcium hemodialysis and mechanism of hypercalcemia. Hsu, S.C., Lee, Y.Y., Wang, M.C., Liu, H.L., Cheng, M.F., Huang, J.J. Blood Purif. (2004) [Pubmed]
  4. Elevated serum interferon gamma and interleukin-6 in patients with necrotizing lymphadenitis (Kikuchi's disease). Kubota, M., Tsukamoto, R., Kurokawa, K., Imai, T., Furusho, K. Br. J. Haematol. (1996) [Pubmed]
  5. Changes in ovine erythrocyte morphology due to sphingomyelin degradation by Corynebacterium pseudotuberculosis phospholipase D. Brogden, K.A., Engen, R.L., Songer, J.G., Gallagher, J. Microb. Pathog. (1990) [Pubmed]
  6. Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease. Race, E.M., Adelson-Mitty, J., Kriegel, G.R., Barlam, T.F., Reimann, K.A., Letvin, N.L., Japour, A.J. Lancet (1998) [Pubmed]
  7. Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. Tessier, M.H., Amoric, J.C., Méchinaud, F., Dubesset, D., Litoux, P., Stalder, J.F. Lancet (1994) [Pubmed]
  8. Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection. Nau, G.J., Chupp, G.L., Emile, J.F., Jouanguy, E., Berman, J.S., Casanova, J.L., Young, R.A. Am. J. Pathol. (2000) [Pubmed]
  9. Immunoreactivity for IL-1 beta and TNF alpha in human lymphoid and nonlymphoid tissues. Ruco, L.P., Stoppacciaro, A., Pomponi, D., Boraschi, D., Santoni, A., Tagliabue, A., Uccini, S., Baroni, C.D. Am. J. Pathol. (1989) [Pubmed]
  10. An ultrastructural study of subacute necrotizing lymphadenitis. Imamura, M., Ueno, H., Matsuura, A., Kamiya, H., Suzuki, T., Kikuchi, K., Onoe, T. Am. J. Pathol. (1982) [Pubmed]
  11. Lymphadenitis associated with the administration of clindamycin. Southern, P.M. Am. J. Med. (1997) [Pubmed]
  12. Failure of treatment of tuberculous adenitis due to an unexpected drug interaction with rifabutin and efavirenz. Edelstein, H.E., Cuadros, Y. AIDS (2004) [Pubmed]
  13. Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis. Sugaya, N., Kanno, T., Nirasawa, M., Mitamura, K., Takeuchi, Y., Osano, M. Clin. Chem. (1990) [Pubmed]
  14. Tuberculous iliac lymphadenitis: a rare complication of intravesical bacillus Calmette-Guerin and cause of tumor over staging. Ali-el Dein, B., Nabeeh, A. J. Urol. (1996) [Pubmed]
  15. Lymphadenitis caused by Scedosporium apiospermum in an immunocompetent patient. Kiraz, N., Gülbas, Z., Akgün, Y., Uzun , O. Clin. Infect. Dis. (2001) [Pubmed]
  16. Infrequent detection of Toxoplasma gondii genome in toxoplasmic lymphadenitis: a polymerase chain reaction study. Weiss, L.M., Chen, Y.Y., Berry, G.J., Strickler, J.G., Dorfman, R.F., Warnke, R.A. Hum. Pathol. (1992) [Pubmed]
  17. Interferon-gamma, interleukin-18, monokine induced by interferon-gamma and interferon-gamma-inducible protein-10 in histiocytic necrotizing lymphadenitis. Ohshima, K., Haraoka, S., Takahata, Y., Takada, H., Tsutiya, K., Suzuk, K., Suzumiya, J., Kikuchi, M. Leuk. Lymphoma (2002) [Pubmed]
  18. Relation of lipid content and exotoxin production to virulence of Corynebacterium pseudotuberculosis in mice. Muckle, C.A., Gyles, C.L. Am. J. Vet. Res. (1983) [Pubmed]
  19. Degree of CD25 expression in T-cell lymphoma is dependent on tissue site: implications for targeted therapy. Jones, D., Ibrahim, S., Patel, K., Luthra, R., Duvic, M., Medeiros, L.J. Clin. Cancer Res. (2004) [Pubmed]
  20. Expression of enolases in B cell tumors. Oka, K., Mori, N., Haimoto, H., Kato, K. Lab. Invest. (1989) [Pubmed]
  21. Calcium oxalate crystal deposition in epithelioid histiocytes of granulomatous lymphadenitis: analysis by light and electronmicroscopy. Symmans, P.J., Brady, K., Keen, C.E. Histopathology (1995) [Pubmed]
  22. Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis. Abe, Y., Ohshima, K., Nakashima, M., Hara, K., Matsushima, T., Choi, I., Nishimura, J., Kikuchi, M., Nawata, H., Watanabe, T., Muta, K. Int. J. Hematol. (2003) [Pubmed]
  23. Immunohistochemical observations on carbonic anhydrase I and II in human salivary glands and submandibular obstructive adenitis. Noda, Y., Sumitomo, S., Hikosaka, N., Mori, M. J. Oral Pathol. (1986) [Pubmed]
  24. Increased production of interferon gamma but not interleukin 4 in human T-lymphotropic virus type I carriers. Shimamoto, Y., Funai, N., Watanabe, M., Suga, K. Int. J. Hematol. (1996) [Pubmed]
  25. Different T-bet expression patterns characterize particular reactive lymphoid tissue lesions. Jöhrens, K., Anagnostopoulos, I., Dürkop, H., Stein, H. Histopathology (2006) [Pubmed]
  26. Differentiation of BCG-induced lymphadenitis from tuberculosis in lymph node biopsy specimens by molecular analyses of pncA and oxyR. Yan, J.J., Chen, F.F., Jin, Y.T., Chang, K.C., Wu, J.J., Wang, Y.W., Su, I.J. J. Pathol. (1998) [Pubmed]
  27. Methicillin-resistant Staphylococcus aureus infections in 2 pediatric outpatients. Feder, H.M. Archives of family medicine. (2000) [Pubmed]
  28. Immunohistochemical detection of cells positive for colony-stimulating factor 1 in lymph nodes from reactive lymphadenitis, and Hodgkin's disease. Moreau, A., Praloran, V., Berrada, L., Coupey, L., Gaillard, F. Leukemia (1992) [Pubmed]
  29. Localized Leishmania lymphadenitis. Immunohistochemical studies. Azadeh, B., Sells, P.G., Ejeckam, G.C., Rampling, D. Am. J. Clin. Pathol. (1994) [Pubmed]
  30. Severe complications of intralesional BCG therapy in an unsensitized patient. Case report and clinical implications. Felix, E.L., Jessup, J.M., Cohen, M.H. Archives of surgery (Chicago, Ill. : 1960) (1978) [Pubmed]
  31. A case of Mycobacterium avium infection: early detection by the auramine-O fluorescent technique. Nussbaum, E., Abramowsky, C. Clinical pediatrics. (1980) [Pubmed]
  32. BCG lymphadenitis in an HIV-infected child 9.5 years after vaccination. Hofstadler, G., Schmitt, K., Tulzer, G., Binder, L., Brandstetter, B. AIDS patient care and STDs. (1998) [Pubmed]
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