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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Edg78E  -  Ecdysone-dependent gene 78E

Drosophila melanogaster

Synonyms: CG7673, DMLCP78, DmelEdg78E, Dmel\CG7673, EDG-78, ...
 
 
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High impact information on Edg78E

  • One of the genes, EDG-78E, encodes a pupal cuticle protein [1].
  • At the onset of metamorphosis, both the cuticle gene Edg78E and the transcription factor betaFTZ-F1 are expressed during the mid- to late prepupal period after a large ecdysteroid pulse [2].
  • Using a transgenic fly reporter assay, a 1.2 kb promoter region of the Edg78E gene has been identified, which was sufficient for appropriate temporally and spatially specific expression of the reporter gene LacZ [2].
  • LacZ expression levels were dramatically reduced in the head and thorax regions but not affected in the abdominal region, suggesting that betaFTZ-F1 is required for high-level Edg78E expression specifically in the head and thorax regions [2].

References

  1. Prepupal differentiation of Drosophila imaginal discs: identification of four genes whose transcripts accumulate in response to a pulse of 20-hydroxyecdysone. Fechtel, K., Natzle, J.E., Brown, E.E., Fristrom, J.W. Genetics (1988) [Pubmed]
  2. BetaFTZ-F1 dependent and independent activation of Edg78E, a pupal cuticle gene, during the early metamorphic period in Drosophila melanogaster. Kawasaki, H., Hirose, S., Ueda, H. Dev. Growth Differ. (2002) [Pubmed]
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