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Gene Review

Pcp  -  Pupal cuticle protein

Drosophila melanogaster

Synonyms: CG3440, DMCPGART, DmelPcp, Dmel\CG3440, Gart, ...
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High impact information on Pcp


Biological context of Pcp


Anatomical context of Pcp

  • In this cell line Gart and Notch are actively transcribed, whereas white is not expressed [5].
  • We conclude that a third EDG encodes a cuticle protein because the conceptual glycine-rich protein contains sequence motifs similar to those found in insect egg shell proteins and vertebrate cytokeratins and because expression of this gene is limited to tissues that deposit the pupal cuticle [9].

Associations of Pcp with chemical compounds

  • Whereas the purine pathway gene is active throughout development, the intronic cuticle protein gene is expressed primarily over a 3 hr period in the abdominal epidermal cells of prepupae that secrete the pupal cuticle [1].
  • We summarize the regulation by JH of the Broad transcription factor that normally appears in the epidermis in the final larval instar and specifies pupal cuticle formation at the metamorphic molt [10].
  • Repair of UV-induced pyrimidine dimers in the individual genes Gart, Notch and white from Drosophila melanogaster cell lines [5].

Other interactions of Pcp


  1. Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands. Henikoff, S., Keene, M.A., Fechtel, K., Fristrom, J.W. Cell (1986) [Pubmed]
  2. The pupal cuticle of Drosophila: biphasic synthesis of pupal cuticle proteins in vivo and in vitro in response to 20-hydroxyecdysone. Doctor, J., Fristrom, D., Fristrom, J.W. J. Cell Biol. (1985) [Pubmed]
  3. Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila melanogaster. Murata, T., Kageyama, Y., Hirose, S., Ueda, H. Mol. Cell. Biol. (1996) [Pubmed]
  4. Prepupal differentiation in Drosophila: distinct cell types elaborate a shared structure, the pupal cuticle, but accumulate transcripts in unique patterns. Fechtel, K., Fristrom, D.K., Fristrom, J.W. Development (1989) [Pubmed]
  5. Repair of UV-induced pyrimidine dimers in the individual genes Gart, Notch and white from Drosophila melanogaster cell lines. de Cock, J.G., Klink, E.C., Ferro, W., Lohman, P.H., Eeken, J.C. Nucleic Acids Res. (1991) [Pubmed]
  6. Genetic analysis of the adenosine3 (Gart) region of the second chromosome of Drosophila melanogaster. Tiong, S.Y., Nash, D. Genetics (1990) [Pubmed]
  7. Evolution of nested genes with special reference to cuticle proteins in Drosophila melanogaster. Moriyama, E.N., Gojobori, T. J. Mol. Evol. (1989) [Pubmed]
  8. Morphogenesis of Drosophila pupal wings in vitro. Turner, C.M., Adler, P.N. Mech. Dev. (1995) [Pubmed]
  9. 20-Hydroxyecdysone is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes. Apple, R.T., Fristrom, J.W. Dev. Biol. (1991) [Pubmed]
  10. Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster. Riddiford, L.M., Hiruma, K., Zhou, X., Nelson, C.A. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  11. BetaFTZ-F1 dependent and independent activation of Edg78E, a pupal cuticle gene, during the early metamorphic period in Drosophila melanogaster. Kawasaki, H., Hirose, S., Ueda, H. Dev. Growth Differ. (2002) [Pubmed]
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