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Gene Review

Hr78  -  Hormone-receptor-like in 78

Drosophila melanogaster

Synonyms: CG7199, DHR78, Dhr78, Dmel\CG7199, HR78, ...
 
 
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Disease relevance of Hr78

  • Moses mutants progress normally through early larval stages, like DHR78 mutants, but display an opposite overgrowth phenotype, with hypertrophy of adult tissues [1].
 

High impact information on Hr78

  • DHR78 protein is bound to many ecdysteroid-regulated puff loci, suggesting that DHR78 directly regulates puff gene expression [2].
  • Consistent with these phenotypes, DHR78 mutants fail to activate the mid-third instar regulatory hierarchy that prepares the animal for metamorphosis [2].
  • DHR78 and DHR96 are orphan receptor genes [3].
  • Using this approach, we isolated three Drosophila genes, designated DHR38, DHR78, and DHR96 [3].
  • DHR78 is induced by 20-hydroxyecdysone (20E) in cultured larval organs, and its encoded protein binds to two AGGTCA half-sites arranged as either direct or palindromic repeats [3].
 

Biological context of Hr78

  • Essential roles for the Dhr78 orphan nuclear receptor during molting of the Drosophila tracheal system [4].
 

Other interactions of Hr78

  • DHR78, which encodes another candidate ecdysteroid receptor, is also not required [5].
  • Conversely, none of the compounds tested had a significant effect on the activity of three Drosophila orphan nuclear receptors: DHR38, DHR78 or DHR96 [6].

References

  1. Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Baker, K.D., Beckstead, R.B., Mangelsdorf, D.J., Thummel, C.S. Genes Dev. (2007) [Pubmed]
  2. The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis. Fisk, G.J., Thummel, C.S. Cell (1998) [Pubmed]
  3. Isolation, regulation, and DNA-binding properties of three Drosophila nuclear hormone receptor superfamily members. Fisk, G.J., Thummel, C.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Essential roles for the Dhr78 orphan nuclear receptor during molting of the Drosophila tracheal system. Astle, J., Kozlova, T., Thummel, C.S. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  5. Broad-complex, but not ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye. Brennan, C.A., Li, T.R., Bender, M., Hsiung, F., Moses, K. Development (2001) [Pubmed]
  6. Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids. Baker, K.D., Warren, J.T., Thummel, C.S., Gilbert, L.I., Mangelsdorf, D.J. Insect Biochem. Mol. Biol. (2000) [Pubmed]
 
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