The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

BNBD-5  -  neutrophil beta-defensin 5

Bos taurus

This record was replaced with 783935.
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of BNBD-5

 

High impact information on BNBD-5

  • Four beta-defensins were expressed constitutively in BAM, with bovine neutrophil beta-defensin (BNBD)-4 and BNBD-5 being the most predominant [2].
  • Values of synonymous and nonsynonymous substitutions demonstrated lap, bnbd5, bnbd9 and nbd12 evolving under positive selection, whereas amino-acid altering substitutions among variants of ebd and tap are purified [3].
  • In situ hybridizations revealed that BNBD5 is expressed predominantly in the mammary epithelial cells (MEC) of the infected gland [4].

References

  1. NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells. Yang, W., Molenaar, A., Kurts-Ebert, B., Seyfert, H.M. Mol. Immunol. (2006) [Pubmed]
  2. Expression of beta-defensin genes in bovine alveolar macrophages. Ryan, L.K., Rhodes, J., Bhat, M., Diamond, G. Infect. Immun. (1998) [Pubmed]
  3. Variability and evolution of bovine beta-defensin genes. Luenser, K., Ludwig, A. Genes Immun. (2005) [Pubmed]
  4. Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Goldammer, T., Zerbe, H., Molenaar, A., Schuberth, H.J., Brunner, R.M., Kata, S.R., Seyfert, H.M. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
 
WikiGenes - Universities