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Gene Review

BNBD-5  -  neutrophil beta-defensin 5

Bos taurus

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Disease relevance of BNBD-5


High impact information on BNBD-5

  • Four beta-defensins were expressed constitutively in BAM, with bovine neutrophil beta-defensin (BNBD)-4 and BNBD-5 being the most predominant [2].
  • Values of synonymous and nonsynonymous substitutions demonstrated lap, bnbd5, bnbd9 and nbd12 evolving under positive selection, whereas amino-acid altering substitutions among variants of ebd and tap are purified [3].
  • In situ hybridizations revealed that BNBD5 is expressed predominantly in the mammary epithelial cells (MEC) of the infected gland [4].


  1. NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells. Yang, W., Molenaar, A., Kurts-Ebert, B., Seyfert, H.M. Mol. Immunol. (2006) [Pubmed]
  2. Expression of beta-defensin genes in bovine alveolar macrophages. Ryan, L.K., Rhodes, J., Bhat, M., Diamond, G. Infect. Immun. (1998) [Pubmed]
  3. Variability and evolution of bovine beta-defensin genes. Luenser, K., Ludwig, A. Genes Immun. (2005) [Pubmed]
  4. Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Goldammer, T., Zerbe, H., Molenaar, A., Schuberth, H.J., Brunner, R.M., Kata, S.R., Seyfert, H.M. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
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