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Gene Review

Cont  -  Contactin

Drosophila melanogaster

Synonyms: CG1084, CONT, CT1481, D-Axonin, DCONT, ...
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High impact information on Cont

  • The cell-adhesion molecules NRX IV/Caspr/Paranodin (NCP1), contactin and Neurofascin-155 (NF-155) are all present at the vertebrate axo-glial SJs [1].
  • Interestingly, the murine homologs of Neurexin IV, Contactin, and Neuroglian are expressed at the paranodal SJs and play a key role in axon-glial interactions of myelinated axons [2].

Anatomical context of Cont


  1. Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function. Faivre-Sarrailh, C., Banerjee, S., Li, J., Hortsch, M., Laval, M., Bhat, M.A. Development (2004) [Pubmed]
  2. Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila. Banerjee, S., Pillai, A.M., Paik, R., Li, J., Bhat, M.A. J. Neurosci. (2006) [Pubmed]
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