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Gene Review

Nrx-IV  -  Neurexin IV

Drosophila melanogaster

Synonyms: CG682, CG6827, CT21123, Dmel\CG6827, Dnrx, ...
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High impact information on Nrx-IV


Anatomical context of Nrx-IV


Physical interactions of Nrx-IV

  • In addition, we present evidence that Mega is essential for localization of the septate junction protein complex Coracle/Neurexin [5].

Other interactions of Nrx-IV

  • We show that CONT, Neuroglian (NRG) (Drosophila homolog of NF-155) and NRX IV are interdependent for their SJ localization and these proteins form a tripartite complex [6].
  • Consistent with this notion, immunoprecipitation and in vitro binding studies demonstrate that the amino-terminal 383 amino acids of Coracle and cytoplasmic domain of Neurexin interact directly [7].
  • Our genetic analysis using a sinuous null mutation suggests that sinuous functions in the same pathway as the septate junction genes neurexin and scribble, but that nervana 2, convoluted, varicose, and cystic have functions not shared by sinuous [8].
  • In Gli mutants, localization of SJ markers neurexin-IV, discs large, and coracle are disrupted [9].
  • Finally, we describe two examples of how Dg promotes the differentiation of the basal membrane domain: (1) by recruiting/anchoring the cytoplasmic protein Dystrophin; and (2) by excluding the transmembrane protein Neurexin [10].


  1. Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Bhat, M.A., Izaddoost, S., Lu, Y., Cho, K.O., Choi, K.W., Bellen, H.J. Cell (1999) [Pubmed]
  2. A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Baumgartner, S., Littleton, J.T., Broadie, K., Bhat, M.A., Harbecke, R., Lengyel, J.A., Chiquet-Ehrismann, R., Prokop, A., Bellen, H.J. Cell (1996) [Pubmed]
  3. Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia. Bellen, H.J., Lu, Y., Beckstead, R., Bhat, M.A. Trends Neurosci. (1998) [Pubmed]
  4. Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila. Banerjee, S., Pillai, A.M., Paik, R., Li, J., Bhat, M.A. J. Neurosci. (2006) [Pubmed]
  5. The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Behr, M., Riedel, D., Schuh, R. Dev. Cell (2003) [Pubmed]
  6. Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function. Faivre-Sarrailh, C., Banerjee, S., Li, J., Hortsch, M., Laval, M., Bhat, M.A. Development (2004) [Pubmed]
  7. A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity. Ward, R.E., Lamb, R.S., Fehon, R.G. J. Cell Biol. (1998) [Pubmed]
  8. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. Wu, V.M., Schulte, J., Hirschi, A., Tepass, U., Beitel, G.J. J. Cell Biol. (2004) [Pubmed]
  9. Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. Schulte, J., Tepass, U., Auld, V.J. J. Cell Biol. (2003) [Pubmed]
  10. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Schneider, M., Khalil, A.A., Poulton, J., Castillejo-Lopez, C., Egger-Adam, D., Wodarz, A., Deng, W.M., Baumgartner, S. Development (2006) [Pubmed]
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