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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cntn3  -  contactin 3

Mus musculus

Synonyms: BIG-1, Brain-derived immunoglobulin superfamily protein 1, Contactin-3, Pang, Pcs, ...
 
 
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Disease relevance of Cntn3

  • The results suggest that Pcs and PmtA have complementary roles in vivo related to nutrient availability and that PC and the membrane properties that depend on this typical eukaryotic phospholipid are essential for Brucella virulence [1].
 

High impact information on Cntn3

  • In rich medium, BApcs and the double mutant BApcspmtA but not BApmtA displayed reduced growth, increased phosphatidylethanolamine and no PC, showing that Pcs is essential for PC synthesis under these conditions [1].
  • To determine whether glial GPDH expression requires the continued presence of Pcs in adults, we used single intracerebellar injections of kainic acid to kill Pcs in wild-type mice from 7 weeks to 11 months old [2].
  • To learn whether a high level of GPDH could be reinduced following down-regulation in Lc Bg, we grafted wild-type fetal Pcs into Lc cerebella [2].
  • Nerve growth factor (NGF)-stimulated neurite outgrowth in the rat PC12 tumor cell line recently has been shown to depend on the activation of the mitogen-activated protein (MAP) kinase kinase 1 (MEK1) (Pang et al.: J Biol Chem 270:13585-13588, 1995) [3].

References

  1. Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus. Conde-Alvarez, R., Grilló, M.J., Salcedo, S.P., de Miguel, M.J., Fugier, E., Gorvel, J.P., Moriyón, I., Iriarte, M. Cell. Microbiol. (2006) [Pubmed]
  2. Bergmann glia require continuous association with Purkinje cells for normal phenotype expression. Fisher, M., Trimmer, P., Ruthel, G. Glia (1993) [Pubmed]
  3. Nerve growth factor-stimulated mitogen-activated protein kinase activity is not necessary for neurite outgrowth of chick dorsal root ganglion sensory and sympathetic neurons. Klinz, F.J., Wolff, P., Heumann, R. J. Neurosci. Res. (1996) [Pubmed]
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