Disease relevance of atpA

• Cytoplasmic male sterility in sunflower is correlated with the co-transcription of a new open reading frame with the atpA gene [1].

High impact information on atpA

• One endpoint of both rearrangements is located within or near atpA, which is also the only mitochondrial gene whose transcripts differ between the fertile and CMS lines [2].
• This rearrangement has resulted in the creation of a new open reading frame (ORFc) which is co-transcribed with atpA in sterile sunflower [3].
• A region of mitochondrial genome variation between the two phenotypes has been located in the 3' flanking region of the gene encoding the alpha subunit of the F1 ATPase (atpA) [3].
• Using the atpA probe, 5 from the 6 investigated CMS genotypes showed identical hybridization patterns to the Petiolaris CMS line, which is used in all commercial sunflower hybrids [4].
• Cytoplasmic male-sterile lines CMS89 and CMSBaso of sunflower (Helianthus annuus) differ from the fertile lines HA89 and Baso in a mitochondrial DNA sequence in the vicinity of the atpA gene [5].

Analytical, diagnostic and therapeutic context of atpA

• Physical mapping and sequence analysis have been used to show that a rearrangement involving an inversion and an insertion has occurred immediately downstream of the atpA coding region in the mitochondrial DNA from sterile sunflower [3].

References