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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MYF5  -  myogenic factor 5

Sus scrofa

 
 
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High impact information on MYF5

  • However, enhanced expression of Myf5 and MyoD indicates higher numbers of initially determined, proliferating myoblasts that may have contributed to increased formation of secondary fibres [1].
  • Genetic variation at the porcine MYF-5 gene locus. Lack Of association with meat production traits [2].
  • Assignment of the porcine loci for MYOD1 to chromosome 2 and MYF5 to chromosome 5 [3].
  • A new SNP in the promoter region of the porcine MYF5 gene has no effect on its transcript level in m. longissimus dorsi [4].
  • The relative content of MYF5 mRNA in m. longissimus dorsi did not differ significantly across MYF5 genotypes (AA, AC, CC) [4].
 

Biological context of MYF5

  • In the promoter region of gene MYF5 we identified three mutations at positions: A65C (PCR-RFLP/AciI); C580T (PCR-RFLP/FokI) and C613T (PCR-RFLP/HinPI) [5].
  • The frequency of particular genotypes at the MYOD1 and MYF5 loci proved to be dependent on pig breed [5].
  • New SNPs in the coding and 5' flanking regions of porcine MYOD1 (MYF3) and MYF5 genes [5].
  • MYOD1 was assigned to pig chromosome 2 and MYF5 to chromosome 5 [3].
  • This result suggests that the A65C transversion may not play an important role in the expression of the MYF5 gene in analysed adult muscle but it abolishes a putative binding site for two transcription factors (CDP and HSF1) and creates such a site for Sp1 [4].

References

  1. Maternal treatment with somatotropin during early gestation affects basic events of myogenesis in pigs. Rehfeldt, C., Kuhn, G., Vanselow, J., Fürbass, R., Fiedler, I., Nürnberg, G., Clelland, A.K., Stickland, N.C., Ender, K. Cell Tissue Res. (2001) [Pubmed]
  2. Genetic variation at the porcine MYF-5 gene locus. Lack Of association with meat production traits. te Pas, M.F., Harders, F.L., Soumillion, A., Born, L., Buist, W., Meuwissen, T.H. Mamm. Genome (1999) [Pubmed]
  3. Assignment of the porcine loci for MYOD1 to chromosome 2 and MYF5 to chromosome 5. Soumillion, A., Rettenberger, G., Vergouwe, M.N., Erkens, J.H., Lenstra, J.A., te Pas, M.F. Anim. Genet. (1997) [Pubmed]
  4. A new SNP in the promoter region of the porcine MYF5 gene has no effect on its transcript level in m. longissimus dorsi. Urbański, P., Flisikowski, K., Starzyński, R.R., Kurył, J., Kamyczek, M. J. Appl. Genet. (2006) [Pubmed]
  5. New SNPs in the coding and 5' flanking regions of porcine MYOD1 (MYF3) and MYF5 genes. Urbański, P., Kurył, J. J. Appl. Genet. (2004) [Pubmed]
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