Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

I-t - inhibitor-t

Drosophila melanogaster

Synonyms: CG14719, Dmel\CG14719, pp1d6

Helps, N.R. et al., Helps, N.R. et al.

Helps, Cohen, Helps, Vergidou, Gaskell, Cohen,

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High impact information on I-t

The mRNA encoding this protein is expressed in both sexes and throughout development, unlike Drosophila inhibitor-t. The bacterially expressed protein was a specific inhibitor of protein phosphatase 1 with an IC(50) of <1 nM, confirming that it is the Drosophila homologue of mammalian inhibitor-2 [1].
The gene for inhibitor-t maps to cytological location 86F1 on the third chromosome [2].
Inhibitor-t mRNA is detected in adult males, larvae and pupae and the 184 amino acid thermostable protein located only in testis [2].

References

Drosophila melanogaster protein phosphatase inhibitor-2: identification of a site important for PP1 inhibition. Helps, N.R., Cohen, P.T. FEBS Lett. (1999) [Pubmed]
Characterisation of a novel Drosophila melanogaster testis specific PP1 inhibitor related to mammalian inhibitor-2: identification of the site of interaction with PP1. Helps, N.R., Vergidou, C., Gaskell, T., Cohen, P.T. FEBS Lett. (1998) [Pubmed]

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