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Gene Review

I-t  -  inhibitor-t

Drosophila melanogaster

Synonyms: CG14719, Dmel\CG14719, pp1d6
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High impact information on I-t

  • The mRNA encoding this protein is expressed in both sexes and throughout development, unlike Drosophila inhibitor-t. The bacterially expressed protein was a specific inhibitor of protein phosphatase 1 with an IC(50) of <1 nM, confirming that it is the Drosophila homologue of mammalian inhibitor-2 [1].
  • The gene for inhibitor-t maps to cytological location 86F1 on the third chromosome [2].
  • Inhibitor-t mRNA is detected in adult males, larvae and pupae and the 184 amino acid thermostable protein located only in testis [2].


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