Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CCR1 - chemokine (C-C motif) receptor 1

Sus scrofa

Futamatsu, H. et al.

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Disease relevance of CCR1

Thus, the CCR1 antagonist may provide a novel therapeutic strategy treatment of myocarditis [1].

High impact information on CCR1

T cell proliferation was inhibited by the CCR1 antagonist [1].
We demonstrated the role of CCR1 on T lymphocytes and the effect of a CCR1 antagonist, BX471 in myocarditis [1].
We confirmed expression of CCR1 in cells infiltrating the myocardium by immunohistochemistry and FACS analysis [1].
CCR1 is a chemokine receptor expressed on neutrophils, monocytes, and T lymphocytes [1].

Analytical, diagnostic and therapeutic context of CCR1

Additionally, we showed by Western blot that the CCR1 antagonist suppressed ERK1/2 and JNK activities in T cells stimulated with myosin and that IL-2 reversed this suppression [1].

References

A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. Futamatsu, H., Suzuki, J., Koga, N., Adachi, S., Kosuge, H., Maejima, Y., Haga, T., Hirao, K., Horuk, R., Isobe, M. J. Mol. Cell. Cardiol. (2006) [Pubmed]

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