Gene Review:
Mapk3 - mitogen activated protein kinase 3
Rattus norvegicus
Synonyms:
ERK-1, ERK1, ERT2, Erk-1, Erk1, ...
- Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Pai, R., Ohta, M., Itani, R.M., Sarfeh, I.J., Tarnawski, A.S. Gastroenterology (1998)
- Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling. Xu, D., Patten, R.D., Force, T., Kyriakis, J.M. Mol. Cell. Biol. (2006)
- CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Schattenberg, J.M., Wang, Y., Rigoli, R.M., Koop, D.R., Czaja, M.J. Hepatology (2004)
- Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes. Post, G.R., Goldstein, D., Thuerauf, D.J., Glembotski, C.C., Brown, J.H. J. Biol. Chem. (1996)
- Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene. Liu, J.C., Baker, R.E., Sun, C., Sundmark, V.C., Elsholtz, H.P. J. Biol. Chem. (2002)
- Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. Pei, J.J., Gong, C.X., An, W.L., Winblad, B., Cowburn, R.F., Grundke-Iqbal, I., Iqbal, K. Am. J. Pathol. (2003)
- Activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats. Cao, J.L., He, J.H., Ding, H.L., Zeng, Y.M. Pain (2005)
- Differential activation of c-Jun N-terminal protein kinase and p38 in rat hippocampus and cerebellum after electroconvulsive shock. Oh, S.W., Ahn, Y.M., Kang, U.G., Kim, Y.S., Park, J.B. Neurosci. Lett. (1999)
- Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus. Guan, Z., Peng, X., Fang, J. Brain Res. (2004)
- Differential patterns of extracellular signal-regulated kinase-1 and -2 phosphorylation in rat limbic brain regions after short-term and long-term inhibitory avoidance learning. Chai, S.C., Holahan, M.R., Shyu, B.C., Wang, C.C. Neuroscience (2006)
- Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis. Acharya, U., Mallabiabarrena, A., Acharya, J.K., Malhotra, V. Cell (1998)
- Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Galve-Roperh, I., Sánchez, C., Cortés, M.L., del Pulgar, T.G., Izquierdo, M., Guzmán, M. Nat. Med. (2000)
- G alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nishida, M., Maruyama, Y., Tanaka, R., Kontani, K., Nagao, T., Kurose, H. Nature (2000)
- Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. Yue, T.L., Gu, J.L., Wang, C., Reith, A.D., Lee, J.C., Mirabile, R.C., Kreutz, R., Wang, Y., Maleeff, B., Parsons, A.A., Ohlstein, E.H. J. Biol. Chem. (2000)
- Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Haider, U.G., Sorescu, D., Griendling, K.K., Vollmar, A.M., Dirsch, V.M. Mol. Pharmacol. (2002)
- Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Aoki, H., Richmond, M., Izumo, S., Sadoshima, J. Biochem. J. (2000)
- Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms. Melien, O., Thoresen, G.H., Sandnes, D., Ostby, E., Christoffersen, T. J. Cell. Physiol. (1998)
- Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. Nguyen, T.V., Yao, M., Pike, C.J. J. Neurochem. (2005)
- Rapid mitogen-activated protein kinase activation by transforming growth factor alpha in wounded rat intestinal epithelial cells. Göke, M., Kanai, M., Lynch-Devaney, K., Podolsky, D.K. Gastroenterology (1998)
- Regulation of both apoptosis and cell survival by the v-Src oncoprotein. Johnson, D., Agochiya, M., Samejima, K., Earnshaw, W., Frame, M., Wyke, J. Cell Death Differ. (2000)
- The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Talarmin, H., Rescan, C., Cariou, S., Glaise, D., Zanninelli, G., Bilodeau, M., Loyer, P., Guguen-Guillouzo, C., Baffet, G. Mol. Cell. Biol. (1999)
- Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Frost, J.A., Alberts, A.S., Sontag, E., Guan, K., Mumby, M.C., Feramisco, J.R. Mol. Cell. Biol. (1994)
- Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways. Cazaubon, S., Chaverot, N., Romero, I.A., Girault, J.A., Adamson, P., Strosberg, A.D., Couraud, P.O. J. Neurosci. (1997)
- Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptor. Murasawa, S., Mori, Y., Nozawa, Y., Gotoh, N., Shibuya, M., Masaki, H., Maruyama, K., Tsutsumi, Y., Moriguchi, Y., Shibazaki, Y., Tanaka, Y., Iwasaka, T., Inada, M., Matsubara, H. Circ. Res. (1998)
- Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Vanhoutte, P., Barnier, J.V., Guibert, B., Pagès, C., Besson, M.J., Hipskind, R.A., Caboche, J. Mol. Cell. Biol. (1999)
- Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK. Thirunavukkarasu, C., Watkins, S.C., Gandhi, C.R. Hepatology (2006)
- Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans. Longuet, C., Broca, C., Costes, S., Hani, e.l. .H., Bataille, D., Dalle, S. Endocrinology (2005)
- Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3',5'-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase. Rossant, C.J., Pinnock, R.D., Hughes, J., Hall, M.D., McNulty, S. Endocrinology (1999)
- Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats. Haberny, S.L., Carr, K.D. Neuroscience (2005)
- Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. Gouni-Berthold, I., Seul, C., Ko, Y., Hescheler, J., Sachinidis, A. Hypertension (2001)
- Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. Sundberg-Smith, L.J., Doherty, J.T., Mack, C.P., Taylor, J.M. J. Biol. Chem. (2005)
- Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Kagiyama, S., Qian, K., Kagiyama, T., Phillips, M.I. Hypertension (2003)
- Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells. Shoba, L.N., Lee, J.C. J. Cell. Biochem. (2003)
- Involvement of hepatocyte epidermal growth factor receptor mediated activation of mitogen-activated protein kinase signaling pathways in response to growth inhibition by a novel K vitamin. Wang, Z., Wang, M., Carr, B.I. J. Cell. Physiol. (2000)
- Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction. Hua, H., Munk, S., Whiteside, C.I. Am. J. Physiol. Renal Physiol. (2003)
- Involvement of p44/42 mitogen-activated protein kinases in regulating angiotensin II- and endothelin-1-induced contraction of rat thoracic aorta. Ishihata, A., Tasaki, K., Katano, Y. Eur. J. Pharmacol. (2002)
- Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway. Ohashi, R., Nakagawa, T., Watanabe, S., Kanellis, J., Almirez, R.G., Schreiner, G.F., Johnson, R.J. Am. J. Pathol. (2004)
- Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations. Rescan, C., Coutant, A., Talarmin, H., Theret, N., Glaise, D., Guguen-Guillouzo, C., Baffet, G. Mol. Biol. Cell (2001)
- EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Traverse, S., Seedorf, K., Paterson, H., Marshall, C.J., Cohen, P., Ullrich, A. Curr. Biol. (1994)
- Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter. Bonello, M.R., Khachigian, L.M. J. Biol. Chem. (2004)
- Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells. Guo, J., Sheng, G., Warner, B.W. J. Biol. Chem. (2005)
- Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells. Cissel, D.S., Beaven, M.A. J. Biol. Chem. (2000)
- Prolactin-induced cell proliferation in PC12 cells depends on JNK but not ERK activation. Cheng, Y., Zhizhin, I., Perlman, R.L., Mangoura, D. J. Biol. Chem. (2000)
- A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology. Ng, D.C., Long, C.S., Bogoyevitch, M.A. J. Biol. Chem. (2001)
- Peroxynitrite targets the epidermal growth factor receptor, Raf-1, and MEK independently to activate MAPK. Zhang, P., Wang, Y.Z., Kagan, E., Bonner, J.C. J. Biol. Chem. (2000)
- Role of osteoclast extracellular signal-regulated kinase (ERK) in cell survival and maintenance of cell polarity. Nakamura, H., Hirata, A., Tsuji, T., Yamamoto, T. J. Bone Miner. Res. (2003)