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Gene Review:

CYP7A1 - cytochrome P450, family 7, subfamily A,...

Gallus gallus

Sato, K. et al., Kang, S. et al.

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High impact information on CYP7A1

FAO cells display the opposite phenotype (i.e. expression of MTP but not CYP7A1) [1].
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) and cholesterol 7 alpha-hydroxylase (CYP7A1), essential enzymes of cholesterol synthesis and excretion, respectively, were isolated from a chicken liver cDNA library [2].
The present study is the first to report the molecular characterization of HMGR and CYP7A1, key enzymes of cholesterol metabolism in avian species [2].
The complete open reading frames of MHGR and CYP7A1 contained (i) 2625 base pairs (bp), predicting a protein of 875 amino acids, and (ii) 1539 bp, predicting a protein of 513 amino acids, respectively [2].

Other interactions of CYP7A1

HMGR and CYP7A1 mRNA levels were significantly increased with maturation (i.e. egg producing), when compared to immature chickens [2].

References

ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. Kang, S., Spann, N.J., Hui, T.Y., Davis, R.A. J. Biol. Chem. (2003) [Pubmed]
Changes in mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in chickens. Sato, K., Ohuchi, A., Sook, S.H., Toyomizu, M., Akiba, Y. Biochim. Biophys. Acta (2003) [Pubmed]

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